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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Clcn4tm1Tjj
targeted mutation 1, Thomas J Jentsch
MGI:4834490
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Clcn4tm1Tjj/Clcn4tm1Tjj involves: 129/Sv * C57BL/6 MGI:4834502
cn2
 		Clcn4tm1Tjj/Clcn4tm1Tjj
Clcn5tm6.1Tjj/Y
Tg(Vil1-cre)20Syr/0 		involves: 129/Sv * C57BL/6 * DBA/2 MGI:4834500
cx3
 		Clcn4tm1Tjj/Clcn4tm1Tjj
Clcn5tm5.1Tjj/Clcn5+ 		involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4834498


Genotype
MGI:4834502
hm1
Allelic
Composition		 Clcn4tm1Tjj/Clcn4tm1Tjj
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn4tm1Tjj mutation (0 available); any Clcn4 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:164474 )
N
• mice exhibit normal urine homeostasis




Genotype
MGI:4834500
cn2
Allelic
Composition		 Clcn4tm1Tjj/Clcn4tm1Tjj
Clcn5tm6.1Tjj/Y
Tg(Vil1-cre)20Syr/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn4tm1Tjj mutation (0 available); any Clcn4 mutation (53 available)
Clcn5tm6.1Tjj mutation (0 available); any Clcn5 mutation (17 available)
Tg(Vil1-cre)20Syr mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal renal protein reabsorption ( J:164474 )
• mice exhibit reduced endocytic uptake of beta-lactoglobulin by proximal tubule cells similar to in Clcn5tm1Tjj homozygotes

homeostasis/metabolism
abnormal renal protein reabsorption ( J:164474 )
• mice exhibit reduced endocytic uptake of beta-lactoglobulin by proximal tubule cells similar to in Clcn5tm1Tjj homozygotes




Genotype
MGI:4834498
cx3
Allelic
Composition		 Clcn4tm1Tjj/Clcn4tm1Tjj
Clcn5tm5.1Tjj/Clcn5+
Genetic
Background		 involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn4tm1Tjj mutation (0 available); any Clcn4 mutation (53 available)
Clcn5tm5.1Tjj mutation (0 available); any Clcn5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:164474 )
N
• receptor-mediated and fluid-phase endocytosis in kidney homogenates are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory