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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nagpatm1Skor
targeted mutation 1, Stuart Kornfeld
MGI:4834497
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nagpatm1Skor/Nagpatm1Skor involves: 129S5/SvEvBrd * C57BL/6 MGI:4834503


Genotype
MGI:4834503
hm1
Allelic
Composition		 Nagpatm1Skor/Nagpatm1Skor
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nagpatm1Skor mutation (0 available); any Nagpa mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased lysosomal enzyme secretion ( J:164482 )
• a 1.6- to 5.4-fold increase in the plasma level of acid hydrolases, however the secreted lysosomal hydrolases contain GlcNAc-P-Man diesters, exhibit a decreased affinity for the cation-independent mannose 6-phosphate receptor and fail to bind to the cation-dependent mannose 6-phosphate receptor




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory