Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(MMTV-PTGS2)#Thla transgene insertion, Timothy Hla MGI:4834855 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike transgenic mice wild-type for Ptger2, 12 week old virgin females do not display precocious mammary gland development
• in contrast to transgenic mice wild-type for Ptger2, few multiparous females develop mammary gland hyperplasia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• virgin females display precocious development at 12 weeks of age
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• seen in multiparous females
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• virgin females display precocious development at 12 weeks of age
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• seen in multiparous females
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in multiparous females
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• in some cases mammary gland adenomatous carcinomas metastasize to peripheral lymph nodes
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• adenomatous carcinomas of the mammary epithelial cells contribute the hyperplastic alveolar nodules that are seen with high frequency in multiparous females
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• delay in the early stages of involution
• however, by 7 days post weaning mammary glands are regressed
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• adenomatous carcinomas of the mammary epithelial cells contribute the hyperplastic alveolar nodules that are seen with high frequency in multiparous females
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• in multiparous females
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• hyperplastic alveolar nodules are seen with high frequency in multiparous females
• alveolar hyperplasia, squamous metaplasia, and adenomatous carcinomas of the mammary epithelial cells contribute to these lesions
|
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• delay in the early stages of involution
• however, by 7 days post weaning mammary glands are regressed
|
|
• adenomatous carcinomas of the mammary epithelial cells contribute the hyperplastic alveolar nodules that are seen with high frequency in multiparous females
|
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• in multiparous females
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• hyperplastic alveolar nodules are seen with high frequency in multiparous females
• alveolar hyperplasia, squamous metaplasia, and adenomatous carcinomas of the mammary epithelial cells contribute to these lesions
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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