About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(MMTV-LPAR1)2Gbm
transgene insertion 2, Gordon B Mills
MGI:4835230
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(MMTV-LPAR1)2Gbm/Tg(MMTV-LPAR1)2Gbm FVB/N-Tg(MMTV-LPAR1)2Gbm MGI:5763090


Genotype
MGI:5763090
tg1
Allelic
Composition		 Tg(MMTV-LPAR1)2Gbm/Tg(MMTV-LPAR1)2Gbm
Genetic
Background		 FVB/N-Tg(MMTV-LPAR1)2Gbm
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:149661 )
• 4 of 19 multiparous females develop mammary carcinomas
• females show varying frequencies of mammary gland hyperplasia, invasive mammary carcinoma and metastasis to other organs
increased mammary gland tumor incidence in breeding females ( J:149661 )
• multiparous, but not virgin, females develop mammary gland carcinomas
mastitis ( J:149661 )
• mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

immune system
mastitis ( J:149661 )
• mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

integument
increased mammary adenocarcinoma incidence ( J:149661 )
• 4 of 19 multiparous females develop mammary carcinomas
• females show varying frequencies of mammary gland hyperplasia, invasive mammary carcinoma and metastasis to other organs
increased mammary gland tumor incidence in breeding females ( J:149661 )
• multiparous, but not virgin, females develop mammary gland carcinomas
mastitis ( J:149661 )
• mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

neoplasm
increased mammary adenocarcinoma incidence ( J:149661 )
• 4 of 19 multiparous females develop mammary carcinomas
• females show varying frequencies of mammary gland hyperplasia, invasive mammary carcinoma and metastasis to other organs
increased mammary gland tumor incidence in breeding females ( J:149661 )
• multiparous, but not virgin, females develop mammary gland carcinomas

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:149661




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory