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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(MMTV-LPAR1)2Gbm
transgene insertion 2, Gordon B Mills
MGI:4835230
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(MMTV-LPAR1)2Gbm/Tg(MMTV-LPAR1)2Gbm FVB/N-Tg(MMTV-LPAR1)2Gbm MGI:5763090


Genotype
MGI:5763090
tg1
Allelic
Composition		 Tg(MMTV-LPAR1)2Gbm/Tg(MMTV-LPAR1)2Gbm
Genetic
Background		 FVB/N-Tg(MMTV-LPAR1)2Gbm
Find Mice Using the International Mouse Strain Resource (IMSR)
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See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:149661 )
• 4 of 19 multiparous females develop mammary carcinomas
• females show varying frequencies of mammary gland hyperplasia, invasive mammary carcinoma and metastasis to other organs
increased mammary gland tumor incidence in breeding females ( J:149661 )
• multiparous, but not virgin, females develop mammary gland carcinomas
mastitis ( J:149661 )
• mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

immune system
mastitis ( J:149661 )
• mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

integument
increased mammary adenocarcinoma incidence ( J:149661 )
• 4 of 19 multiparous females develop mammary carcinomas
• females show varying frequencies of mammary gland hyperplasia, invasive mammary carcinoma and metastasis to other organs
increased mammary gland tumor incidence in breeding females ( J:149661 )
• multiparous, but not virgin, females develop mammary gland carcinomas
mastitis ( J:149661 )
• mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

neoplasm
increased mammary adenocarcinoma incidence ( J:149661 )
• 4 of 19 multiparous females develop mammary carcinomas
• females show varying frequencies of mammary gland hyperplasia, invasive mammary carcinoma and metastasis to other organs
increased mammary gland tumor incidence in breeding females ( J:149661 )
• multiparous, but not virgin, females develop mammary gland carcinomas

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:149661




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory