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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(MMTV-LPAR2)6Gbm
transgene insertion 6, Gordon B Mills
MGI:4835235
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(MMTV-LPAR2)6Gbm/Tg(MMTV-LPAR2)6Gbm FVB/N-Tg(MMTV-LPAR2)6Gbm MGI:5763104


Genotype
MGI:5763104
tg1
Allelic
Composition		 Tg(MMTV-LPAR2)6Gbm/Tg(MMTV-LPAR2)6Gbm
Genetic
Background		 FVB/N-Tg(MMTV-LPAR2)6Gbm
Find Mice Using the International Mouse Strain Resource (IMSR)
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See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland morphology ( J:149661 )
• mammary glands from virgin females show a slight increase in side branching
increased mammary adenocarcinoma incidence ( J:149661 )
• 15 of 28 multiparous females develop mammary carcinomas
• females show varying frequencies of mammary gland hyperplasia, mammary intraepithelial neoplasia, and invasive mammary carcinoma
increased mammary gland tumor incidence in breeding females ( J:149661 )
• multiparous, but not virgin, females develop mammary gland carcinomas
mastitis ( J:149661 )
• mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

immune system
mastitis ( J:149661 )
• mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

integument
abnormal mammary gland morphology ( J:149661 )
• mammary glands from virgin females show a slight increase in side branching
increased mammary adenocarcinoma incidence ( J:149661 )
• 15 of 28 multiparous females develop mammary carcinomas
• females show varying frequencies of mammary gland hyperplasia, mammary intraepithelial neoplasia, and invasive mammary carcinoma
increased mammary gland tumor incidence in breeding females ( J:149661 )
• multiparous, but not virgin, females develop mammary gland carcinomas
mastitis ( J:149661 )
• mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

neoplasm
increased mammary adenocarcinoma incidence ( J:149661 )
• 15 of 28 multiparous females develop mammary carcinomas
• females show varying frequencies of mammary gland hyperplasia, mammary intraepithelial neoplasia, and invasive mammary carcinoma
increased mammary gland tumor incidence in breeding females ( J:149661 )
• multiparous, but not virgin, females develop mammary gland carcinomas

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:149661




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory