About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		PrkcbM1Btlr
mutation 1, Bruce Beutler
MGI:4835545
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		PrkcbM1Btlr/PrkcbM1Btlr C57BL/6J-PrkcbM1Btlr MGI:4835548
hm2
 		PrkcbM1Btlr/PrkcbM1Btlr involves: C57BL/6J MGI:5429191
ht3
 		PrkcbM1Btlr/Prkcb+ C57BL/6J-PrkcbM1Btlr MGI:4835547


Genotype
MGI:4835548
hm1
Allelic
Composition		 PrkcbM1Btlr/PrkcbM1Btlr
Genetic
Background		 C57BL/6J-PrkcbM1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkcbM1Btlr mutation (1 available); any Prkcb mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:164864 )
• mice homozygous for this mutation display a severely reduced IgM antibody response to the T cell-independent model antigen 2,4,6-trinitrophenyl (TNP)-Ficoll

hematopoietic system
decreased IgM level ( J:164864 )
• mice homozygous for this mutation display a severely reduced IgM antibody response to the T cell-independent model antigen 2,4,6-trinitrophenyl (TNP)-Ficoll




Genotype
MGI:5429191
hm2
Allelic
Composition		 PrkcbM1Btlr/PrkcbM1Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkcbM1Btlr mutation (1 available); any Prkcb mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:185495 )
N
• mice exhibit normal peripheral blood lymphocytes
• mice exhibit a normal response to recombinant Semliki Forest virus (SFV) encoded antigen
decreased IgM level ( J:185495 )
• following NP-Ficoll immunization

hematopoietic system
decreased IgM level ( J:185495 )
• following NP-Ficoll immunization




Genotype
MGI:4835547
ht3
Allelic
Composition		 PrkcbM1Btlr/Prkcb+
Genetic
Background		 C57BL/6J-PrkcbM1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkcbM1Btlr mutation (1 available); any Prkcb mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:164864 )
• mice heterozygous for this mutation display a reduced IgM antibody response to the T cell-independent model antigen 2,4,6-trinitrophenyl (TNP)-Ficoll, intermediate between the responses of wild-type and homozygous mutant mice

hematopoietic system
decreased IgM level ( J:164864 )
• mice heterozygous for this mutation display a reduced IgM antibody response to the T cell-independent model antigen 2,4,6-trinitrophenyl (TNP)-Ficoll, intermediate between the responses of wild-type and homozygous mutant mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory