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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrp3m2Btlr
mutation 2, Bruce Beutler
MGI:4835549
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
 		Nlrp3m2Btlr/? C57BL/6J-Nlrp3m2Btlr MGI:4835550


Genotype
MGI:4835550
ot1
Allelic
Composition		 Nlrp3m2Btlr/?
Genetic
Background		 C57BL/6J-Nlrp3m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3m2Btlr mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal interleukin-1 beta secretion ( J:164865 )
• peritoneal macrophages from mice with this mutation exhibit a reduced interleukin-beta response to lipopolysaccharide, a toll-like receptor 4 (TLR4) ligand, plus nigericin (NALP3 Inflammasome Screen)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory