Phenotypes associated with this allele

• Allele Symbol: Runx1^{tm1.1(RUNX1*)Homy}
• Allele Name: targeted mutation 1.1, Hiroaki Honda
• Allele ID: MGI:4835663
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Runx1^tm1.1(RUNX1*)Homy/Runx1^tm1.1(RUNX1*)Homy	B6.129P2-Runx1^tm1.1(RUNX1*)Homy	MGI:4835666

Genotype
MGI:4835666

hm1

• Allelic Composition: Runx1^{tm1.1(RUNX1*)Homy}/Runx1^{tm1.1(RUNX1*)Homy}
• Genetic Background: B6.129P2-Runx1^{tm1.1(RUNX1*)Homy}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:164806 )

• die at about E14.5

cardiovascular system

abnormal pericyte morphology ( J:164806 )

• expression analysis indicates that subcutaneous vessels have fewer associated pericytes

• however, vessels in other organs, such as the brain, appear to have normal numbers of pericytes

dilated vasculature ( J:164806 )

• at E13.5 marked vessel dilation is seen mainly in the trunk

aneurysm ( J:164806 )

• peripheral blood vessels occasionally form microaneurysms with hemorrhage

hemorrhage ( J:164806 )

• peripheral blood vessels occasionally form microaneurysms with hemorrhage

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:164806 )

• decrease in the proportion of megakaryocyte/erythrocyte fraction and an increase in the common myeloid progenitor and granulocyte/macrophage progenitor fractions in the fetal liver

impaired hematopoiesis ( J:164806 )

• the hematopoietic colony forming units (CFU) are markedly reduced compared to control littermates

• fetal liver cells show impaired repopulation ability in a competitive repopulation assay

decreased erythroid progenitor cell number ( J:164806 )

• marked decrease in CFU-E

abnormal megakaryocyte progenitor cell morphology ( J:164806 )

• while single megakaryocytes are seen no megakaryocytic colonies are generated by fetal liver cells in vitro

decreased hematopoietic cell number ( J:164806 )

• the fetal liver contains fewer hematopoietic cells

liver/biliary system

pale liver ( J:164806 )

• the fetal liver contains fewer hematopoietic cells

homeostasis/metabolism

skin edema ( J:164806 )

• at E13.5

integument

skin edema ( J:164806 )

• at E13.5