Phenotypes associated with this allele

• Allele Symbol: Tg(Pdgfrb-cre)#Rha
• Allele Name: transgene insertion, Ralf H Adams
• Allele ID: MGI:4835938
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Angpt1^tm1.1Seq/Angpt1^tm1.2Seq Tg(Pdgfrb-cre)#Rha/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5140327
cn2	Insr^tm1Khn/Insr^tm1Khn Tg(Pdgfrb-cre)#Rha/0	involves: 129S4/SvJae * C57BL/6J	MGI:7327617

Genotype
MGI:5140327

cn1

• Allelic Composition: Angpt1^tm1.1Seq/Angpt1^tm1.2Seq; Tg(Pdgfrb-cre)#Rha/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal renal glomerulus morphology ( J:174022 )

• mice treated with doxycycline since E16.5 and exposed to STZ to induce diabetes exhibit accelerated glomerular damage compared with similarly treated control mice

Genotype
MGI:7327617

cn2

• Allelic Composition: Insr^tm1Khn/Insr^tm1Khn; Tg(Pdgfrb-cre)#Rha/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

vision/eye

abnormal retina vasculature morphology ( J:327000 )

• mice show increased vascularity in the regions adjacent to retinal veins

• the number of sprouting tip cells is increased indicating increased angiogenic sporouting in superficial and deep layers

• however, pericyte coverage of capillaries is unaltered in perivenous and periartieral plexi and no differences in vascular regression or endothelial proliferation is seen

abnormal retina blood vessel morphology ( J:327000 )

• mice show increased retinal vein diameter at P5 and P10

abnormal retina blood vessel pattern ( J:327000 )

• mice show impaired venous pattering during developmental retinal angiogenesis with increased branching complexity in the peripheral half of the plexus at P5

cardiovascular system

abnormal retina vasculature morphology ( J:327000 )

• mice show increased vascularity in the regions adjacent to retinal veins

• the number of sprouting tip cells is increased indicating increased angiogenic sporouting in superficial and deep layers

• however, pericyte coverage of capillaries is unaltered in perivenous and periartieral plexi and no differences in vascular regression or endothelial proliferation is seen

abnormal retina blood vessel morphology ( J:327000 )

• mice show increased retinal vein diameter at P5 and P10

abnormal retina blood vessel pattern ( J:327000 )

• mice show impaired venous pattering during developmental retinal angiogenesis with increased branching complexity in the peripheral half of the plexus at P5

abnormal vascular plexus formation ( J:327000 )

• mice exhibit abnormal retinal venous plexus development in early postnatal life, with increased branching complexity in the peripheral half of the plexus, increased venous plexus vascular density but not arterial plexus density, and increased vascular area of the deep vascular plexus indicating venous plexus hypervascularity

• perivenous hypervascularity diminishes with time, although it is still evident at P10

homeostasis/metabolism

increased circulating insulin level ( J:327000 )

• fasting serum insulin is increased in 8-week-old mice

• however, fasting serum glucose is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
diabetic retinopathy		DOID:8947		J:327000