All Phenotypes Irf8<M1Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Irf8^M1Btlr
mutation 1, Bruce Beutler
MGI:4835995

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irf8^M1Btlr/Irf8^M1Btlr	C57BL/6J-Irf8^M1Btlr	MGI:4839976

Allelic Composition	Irf8^M1Btlr/Irf8^M1Btlr
Genetic Background	C57BL/6J-Irf8^M1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8^M1Btlr mutation (1 available); any Irf8 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased neutrophil cell number ( J:166600 )

decreased macrophage cell number ( J:166600 )

• decreased numbers of mature macrophages

decreased monocyte cell number ( J:166600 )

immune system

increased neutrophil cell number ( J:166600 )

decreased macrophage cell number ( J:166600 )

• decreased numbers of mature macrophages

decreased monocyte cell number ( J:166600 )

abnormal interferon secretion ( J:166600 )

• non-secretion of type I interferon by plasmacytoid dendritic cells (pDCs) in response to in vivo stimulation by the toll-like receptor ligand, CpG

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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