All Phenotypes Slc15a4<m1Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc15a4^m1Btlr
mutation 1, Bruce Beutler
MGI:4835997

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc15a4^m1Btlr/Slc15a4^m1Btlr	C57BL/6J-Slc15a4^m1Btlr	MGI:4839962

Allelic Composition	Slc15a4^m1Btlr/Slc15a4^m1Btlr
Genetic Background	C57BL/6J-Slc15a4^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc15a4^m1Btlr mutation (1 available); any Slc15a4 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal interferon secretion ( J:166600 )

• in vivo challenge with TLR7 or TLR9 ligands fails to produce type 1 interferon secretion in plasmacytoid dendritic cells; conventional dendritic cells respond normally to TLR ligands

decreased interleukin-12 secretion ( J:166600 )

• in vitro challenge with TLR7 or TLR9 ligands fails to produce IL12 secretion in plasmacytoid dendritic cells

decreased interleukin-6 secretion ( J:166600 )

• in vitro challenge with TLR7 or TLR9 ligands fails to produce IL6 secretion in plasmacytoid dendritic cells

decreased tumor necrosis factor secretion ( J:166600 )

• in vitro challenge with TLR7 or TLR9 ligands fails to produce TNFalpha secretion in plasmacytoid dendritic cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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