All Phenotypes Slc15a4<m1Btlr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc15a4^m1Btlr
mutation 1, Bruce Beutler
MGI:4835997

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc15a4^m1Btlr/Slc15a4^m1Btlr	C57BL/6J-Slc15a4^m1Btlr	MGI:4839962

Allelic Composition	Slc15a4^m1Btlr/Slc15a4^m1Btlr
Genetic Background	C57BL/6J-Slc15a4^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc15a4^m1Btlr mutation (1 available); any Slc15a4 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal interferon secretion ( J:166600 )

• in vivo challenge with TLR7 or TLR9 ligands fails to produce type 1 interferon secretion in plasmacytoid dendritic cells; conventional dendritic cells respond normally to TLR ligands

decreased interleukin-12 secretion ( J:166600 )

• in vitro challenge with TLR7 or TLR9 ligands fails to produce IL12 secretion in plasmacytoid dendritic cells

decreased interleukin-6 secretion ( J:166600 )

• in vitro challenge with TLR7 or TLR9 ligands fails to produce IL6 secretion in plasmacytoid dendritic cells

decreased tumor necrosis factor secretion ( J:166600 )

• in vitro challenge with TLR7 or TLR9 ligands fails to produce TNFalpha secretion in plasmacytoid dendritic cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24