About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prkaa1tm1.1Sjm
targeted mutation 1.1, Sean J Morrison
MGI:4836199
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Prkaa1tm1.1Sjm/Prkaa1tm1.1Sjm
Prkaa2tm1.1Sjm/Prkaa2tm1.1Sjm
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA * SJL MGI:4840217


Genotype
MGI:4840217
cn1
Allelic
Composition		 Prkaa1tm1.1Sjm/Prkaa1tm1.1Sjm
Prkaa2tm1.1Sjm/Prkaa2tm1.1Sjm
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa1tm1.1Sjm mutation (1 available); any Prkaa1 mutation (46 available)
Prkaa2tm1.1Sjm mutation (1 available); any Prkaa2 mutation (35 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:165090 )
N
• hematopoietic stem cells numbers and long-term multi-lineage reconstitution function are normal in pIpC-treated mice
decreased hematopoietic stem cell number ( J:165090 )
• 2-fold in pIpC treated mice

cellular
cellular phenotype ( J:165090 )
N
• hematopoietic stem cells from pIpC treated mice exhibit normal reactive oxygen species or aneuploidy in culture
increased mitochondrial fission ( J:165090 )
• in the hematopoietic stem cells of pIpC-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory