Phenotypes associated with this allele

• Allele Symbol: Nlrp12^tm1Jpyt
• Allele Name: targeted mutation 1, Jenny P Y Ting
• Allele ID: MGI:4836357
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlrp12^tm1Jpyt/Nlrp12^tm1Jpyt	B6.Cg-Nlrp12^tm1Jpyt	MGI:4836358
hm2	Nlrp12^tm1Jpyt/Nlrp12^tm1Jpyt	Not Specified	MGI:5085873

Genotype
MGI:4836358

hm1

• Allelic Composition: Nlrp12^tm1Jpyt/Nlrp12^tm1Jpyt
• Genetic Background: B6.Cg-Nlrp12^tm1Jpyt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired neutrophil chemotaxis ( J:164725 )

• migration of neutrophils to the neutrophil-attracting chemokine CXCL1 is reduced by 50% when compared with wild-type neutrophils

abnormal leukocyte migration ( J:164725 )

• abnormal dendritic cell migartion as measured by the decreased accumulation of peripheral antigen in the draining lymph node, non-draining lymph node, bone marrow or spleen

• hapten application to skin does not result in dendritic cell egress as it does in wild-type mice

• reduced migration toward CCR7 and CXCR4 ligands CCL19, CCL21A, and CXCL12 in an in vitro transwell assay

decreased neutrophil cell number ( J:164725 )

• the accumulation of myeloperoxidase-positive neutrophils in the skin is significantly reduced in hapten-treated ears compared with wild-type mice

decreased susceptibility to type IV hypersensitivity reaction ( J:164725 )

• after mice are sensitized topically on the abdomen with either oxazolone or FITC and elicited 5 d later on the ear there is significantly reduced swelling and reduced cellular accumulation at the site of elicitation

hematopoietic system

impaired neutrophil chemotaxis ( J:164725 )

• migration of neutrophils to the neutrophil-attracting chemokine CXCL1 is reduced by 50% when compared with wild-type neutrophils

abnormal leukocyte migration ( J:164725 )

• abnormal dendritic cell migartion as measured by the decreased accumulation of peripheral antigen in the draining lymph node, non-draining lymph node, bone marrow or spleen

• hapten application to skin does not result in dendritic cell egress as it does in wild-type mice

• reduced migration toward CCR7 and CXCR4 ligands CCL19, CCL21A, and CXCL12 in an in vitro transwell assay

decreased neutrophil cell number ( J:164725 )

• the accumulation of myeloperoxidase-positive neutrophils in the skin is significantly reduced in hapten-treated ears compared with wild-type mice

cellular

impaired neutrophil chemotaxis ( J:164725 )

• migration of neutrophils to the neutrophil-attracting chemokine CXCL1 is reduced by 50% when compared with wild-type neutrophils

abnormal leukocyte migration ( J:164725 )

• abnormal dendritic cell migartion as measured by the decreased accumulation of peripheral antigen in the draining lymph node, non-draining lymph node, bone marrow or spleen

• hapten application to skin does not result in dendritic cell egress as it does in wild-type mice

• reduced migration toward CCR7 and CXCR4 ligands CCL19, CCL21A, and CXCL12 in an in vitro transwell assay

Genotype
MGI:5085873

hm2

• Allelic Composition: Nlrp12^tm1Jpyt/Nlrp12^tm1Jpyt
• Genetic Background: Not Specified

immune system

immune system phenotype ( J:173245 )

N • mice co-housed with wild-type mice do not affect the susceptibility to induced colitis of wild-type mice