Phenotypes associated with this allele

• Allele Symbol: Nedd4l^andi
• Allele Name: adult nephrogenic diabetes insipidus
• Allele ID: MGI:4836397
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nedd4l^andi/Nedd4l^andi	BALB/cByJ-Nedd4l^andi/EiJ	MGI:4836960

Genotype
MGI:4836960

hm1

• Allelic Composition: Nedd4l^andi/Nedd4l^andi
• Genetic Background: BALB/cByJ-Nedd4l^andi/EiJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

decreased urine osmolality ( J:165173 , J:165247 )

• onset is observed between 5 and 6 weeks of age using a refractometer, and the fact that the urine is very dilute is confirmed by very low uring potassium, soduim, and chloride levels (J:165247)

hydronephrosis ( J:165173 )

• develops in older mutants, onset approximately 38 weeks of age

abnormal renal tubule morphology ( J:165247 )

• inflated lumen, high proximal convoluted tubule brush borders, thickened basement membranes and crowded epithelial cells although the glomeruli appear normal

polyuria ( J:165173 , J:165247 )

• onset is observed between 4 and 6 weeks of age and progresses, with several fold higher than normal water intake and urine output (J:165247)

behavior/neurological

polydipsia ( J:165173 , J:165247 )

• onset is observed between 4 and 6 weeks of age and progresses, with several fold higher than normal water intake and urine output (J:165247)

homeostasis/metabolism

decreased urine osmolality ( J:165173 , J:165247 )

• onset is observed between 5 and 6 weeks of age using a refractometer, and the fact that the urine is very dilute is confirmed by very low uring potassium, soduim, and chloride levels (J:165247)