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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nedd4tm2Bros
targeted mutation 2, Nils Brose
MGI:4836403
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nedd4tm2Bros/Nedd4tm2Bros involves: C57BL/6N MGI:4836484


Genotype
MGI:4836484
hm1
Allelic
Composition
Nedd4tm2Bros/Nedd4tm2Bros
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nedd4tm2Bros mutation (0 available); any Nedd4 mutation (116 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although some mice are present E18.5, no mice are present at birth

nervous system
N
• mice exhibit normal neuronal viability and presynaptic release probability
• mice exhibit normal kainic acid-induced currents
• neurons exhibit normal synapse density per dendrite length, presynaptic maturation of synapses, and spatial matching of pre-and postsynapses
• cultured neurons are smaller than similarly treated wild-type neurons
• however, neuron survival in culture is normal
• dendrites are more immature (shorter with less branching) than on wild-type neurons
• however, initial neuritogenesis is normal
• the number of Synapsin+ presynaptic puncta is reduced compared to in wild-type neurons
• the number of Synapsin+ and Bassoon+ synpatic puncta is decreased compared to in wild-type neurons
• the size of the readily releasable vesicle pool is decreased compared to in wild-type neurons
• the amplitude of excitatory postsynaptic currents is reduced compared to in wild-type mice
• the frequency of miniature excitatory postsynaptic currents (mEPSCs) is reduced compared to in wild-type mice
• however, the amplitude of mEPSCs is normal

cardiovascular system
• 50% of mice exhibit subcutaneous bleeding

growth/size/body
• beginning at E11.5





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory