Phenotypes associated with this allele

• Allele Symbol: Arid1a^tm1.1Gusa
• Allele Name: targeted mutation 1.1, Guy Sauvageau
• Allele ID: MGI:4836625
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arid1a^tm1.1Gusa/Arid1a^tm1.1Gusa	B6.129-Arid1a^tm1.1Gusa	MGI:4836658
hm2	Arid1a^tm1.1Gusa/Arid1a^tm1.1Gusa	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4836657

Genotype
MGI:4836658

hm1

• Allelic Composition: Arid1a^tm1.1Gusa/Arid1a^tm1.1Gusa
• Genetic Background: B6.129-Arid1a^tm1.1Gusa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:164526 )

• mice do not survive beyond birth

hematopoietic system

increased hematopoietic stem cell number ( J:164526 )

• 2-fold in the fetal liver at E14.5

abnormal hematopoietic system physiology ( J:164526 )

• hematopoietic stem cell (HSC) supporting ability in the fetal liver is enhanced compared to in wild-type mice

• however, HSC proliferation and self-renewal activity are normal

Genotype
MGI:4836657

hm2

• Allelic Composition: Arid1a^tm1.1Gusa/Arid1a^tm1.1Gusa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

neonatal lethality, complete penetrance ( J:164526 )

• mice do not survive beyond birth