About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr152tm5.1Cog
targeted mutation 5.1, Michel Cogne
MGI:4836663
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr152tm5.1Cog/Rr152tm5.1Cog involves: 129P2/OlaHsd * C57BL/6 MGI:4836676


Genotype
MGI:4836676
hm1
Allelic
Composition		 Rr152tm5.1Cog/Rr152tm5.1Cog
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr152tm5.1Cog mutation (2 available); any Rr152 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:164513 )
• B cells stimulated with LPS and appropriate cytokines exhibit reduced secretion of IgM and other isotypes compared with similarly treated wild-type cells
abnormal somatic hypermutation frequency ( J:164513 , J:333348 )
• normal SHM in fetal liver B1 B cells (J:333348)
• 38% reduction in SHM in Igh-V region in B1 B cells (J:333348)

hematopoietic system
abnormal class switch recombination ( J:164513 )
• B cells stimulated with LPS and appropriate cytokines exhibit reduced secretion of IgM and other isotypes compared with similarly treated wild-type cells
abnormal somatic hypermutation frequency ( J:164513 , J:333348 )
• normal SHM in fetal liver B1 B cells (J:333348)
• 38% reduction in SHM in Igh-V region in B1 B cells (J:333348)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory