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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm5.1Cog
targeted mutation 5.1, Michel Cogne
MGI:4836663
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ightm5.1Cog/Ightm5.1Cog involves: 129P2/OlaHsd * C57BL/6 MGI:4836676


Genotype
MGI:4836676
hm1
Allelic
Composition		 Ightm5.1Cog/Ightm5.1Cog
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm5.1Cog mutation (2 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:164513 )
• B cells stimulated with LPS and appropriate cytokines exhibit reduced secretion of IgM and other isotypes compared with similarly treated wild-type cells
abnormal somatic hypermutation frequency ( J:164513 , J:333348 )
• normal SHM in fetal liver B1 B cells (J:333348)
• 38% reduction in SHM in Igh-V region in B1 B cells (J:333348)

hematopoietic system
abnormal class switch recombination ( J:164513 )
• B cells stimulated with LPS and appropriate cytokines exhibit reduced secretion of IgM and other isotypes compared with similarly treated wild-type cells
abnormal somatic hypermutation frequency ( J:164513 , J:333348 )
• normal SHM in fetal liver B1 B cells (J:333348)
• 38% reduction in SHM in Igh-V region in B1 B cells (J:333348)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory