Phenotypes associated with this allele

• Allele Symbol: Lclat1^tm1Yugs
• Allele Name: targeted mutation 1, Yuguang Shi
• Allele ID: MGI:4836722
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lclat1^tm1Yugs/Lclat1^tm1Yugs	B6.Cg-Lclat1^tm1Yugs	MGI:4836750

Genotype
MGI:4836750

hm1

• Allelic Composition: Lclat1^tm1Yugs/Lclat1^tm1Yugs
• Genetic Background: B6.Cg-Lclat1^tm1Yugs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:163077 )

• male mice fed a high fat diet exhibit reduced serum glucose during a glucose tolerance test or following insulin injection compared with similarly treated wild-type mice

decreased circulating insulin level ( J:163077 )

• in male mice fed a high fat diet

increased energy expenditure ( J:163077 )

• in male mice fed a high fat diet

decreased susceptibility to diet-induced obesity ( J:163077 )

• when male mice are fed a high fat diet

• however, female mice fed a high fat diet exhibit normal weight gain

increased oxygen consumption ( J:163077 )

• male mice fed a high fat diet exhibit increased oxygen consumption in the liver and skeletal muscles compared with similarly treated wild-type mice

increased respiratory quotient ( J:163077 )

• in male mice fed a high fat diet

increased insulin sensitivity ( J:163077 )

• in male mice fed a high fat diet

abnormal lipid homeostasis ( J:163077 )

• male mice fed a high fat diet exhibit increased linoleic acid content in the heart and increased phosphatidylglycerol in the liver compared with similarly treated wild-type mice

increased fatty acid oxidation ( J:163077 )

• male mice fed a high fat diet exhibit increased fatty acid oxidation compared with wild-type mice

adipose tissue

decreased brown adipose tissue mass ( J:163077 )

• in male mice fed a high fat diet

decreased brown fat cell lipid droplet size ( J:163077 )

• in male mice fed a high fat diet

decreased white fat cell lipid droplet size ( J:163077 )

• in male mice fed a high fat diet

decreased white adipose tissue mass ( J:163077 )

• in male mice fed a high fat diet

behavior/neurological

polydipsia ( J:163077 )

• in male mice fed a high fat diet

polyphagia ( J:163077 )

• in male mice fed a high fat diet

hyperactivity ( J:163077 )

• in male mice fed a high fat diet

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:163077 )

• mitochondria from male mice fed a high fat diet exhibit enhanced complex I activity compared with mitochondrial from similarly treated wild-type mice

increased fatty acid oxidation ( J:163077 )

• male mice fed a high fat diet exhibit increased fatty acid oxidation compared with wild-type mice

growth/size/body

decreased susceptibility to diet-induced obesity ( J:163077 )

• when male mice are fed a high fat diet

• however, female mice fed a high fat diet exhibit normal weight gain