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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tfpitm1.1Rdsi
targeted mutation 1.1, Robert D Simari
MGI:4836740
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tfpitm1.1Rdsi/Tfpitm1.1Rdsi
Tg(Tek-cre)12Flv/0 		B6.Cg-Tfpitm1.1Rdsi Tg(Tek-cre)12Flv MGI:4836841
cn2
 		Tfpitm1.1Rdsi/Tfpitm1.1Rdsi
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * BALB/cJ * C57BL/6 MGI:4836842
cn3
 		Tfpitm1.1Rdsi/Tfpitm1.1Rdsi
Tg(Tek-cre)12Flv/0 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/cJ * C3H * C57BL/6 MGI:4836837
cn4
 		Tfpitm1.1Rdsi/Tfpitm1.1Rdsi
Tg(CMV-cre)1Cgn/Y 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/cJ * C57BL/6 MGI:4836749


Genotype
MGI:4836841
cn1
Allelic
Composition		 Tfpitm1.1Rdsi/Tfpitm1.1Rdsi
Tg(Tek-cre)12Flv/0
Genetic
Background		 B6.Cg-Tfpitm1.1Rdsi Tg(Tek-cre)12Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfpitm1.1Rdsi mutation (1 available); any Tfpi mutation (47 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal circulating protein level ( J:164530 )
• decreased tissue factor pathway inhibitor protein level and activity




Genotype
MGI:4836842
cn2
Allelic
Composition		 Tfpitm1.1Rdsi/Tfpitm1.1Rdsi
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Tfpitm1.1Rdsi mutation (1 available); any Tfpi mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal circulating protein level ( J:164530 )
• decreased tissue factor pathway inhibitor protein activity




Genotype
MGI:4836837
cn3
Allelic
Composition		 Tfpitm1.1Rdsi/Tfpitm1.1Rdsi
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/cJ * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfpitm1.1Rdsi mutation (1 available); any Tfpi mutation (47 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal circulating protein level ( J:164530 )
• decreased tissue factor pathway inhibitor protein level and activity
increased susceptibility to induced thrombosis ( J:164530 )
• in a FeCl3 arterial injury model, carotid arteries become occluded faster than in control mice




Genotype
MGI:4836749
cn4
Allelic
Composition		 Tfpitm1.1Rdsi/Tfpitm1.1Rdsi
Tg(CMV-cre)1Cgn/Y
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfpitm1.1Rdsi mutation (1 available); any Tfpi mutation (47 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory