Phenotypes associated with this allele

• Allele Symbol: Trpv3^tm1.2Clph
• Allele Name: targeted mutation 1.2, David E Clapham
• Allele ID: MGI:4836903
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpv3^tm1.2Clph/Trpv3^tm1.2Clph	B6.129S4-Trpv3^tm1.2Clph	MGI:4836905
hm2	Trpv3^tm1.2Clph/Trpv3^tm1.2Clph	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA	MGI:4836907

Genotype
MGI:4836905

hm1

• Allelic Composition: Trpv3^tm1.2Clph/Trpv3^tm1.2Clph
• Genetic Background: B6.129S4-Trpv3^tm1.2Clph

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

waved hair ( J:164741 )

• with 100% penetrance

curly vibrissae ( J:164741 )

• with 100% penetrance

Genotype
MGI:4836907

hm2

• Allelic Composition: Trpv3^tm1.2Clph/Trpv3^tm1.2Clph
• Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA

immune system

erythroderma ( J:164741 )

integument

erythroderma ( J:164741 )

waved hair ( J:164741 )

• with 100% penetrance

abnormal hair follicle orientation ( J:164741 )

• gently curved and pointed in different directions with variable angles

curly vibrissae ( J:164741 )

• curly morphology is apparent at birth with 100% penetrance

abnormal epidermis stratum corneum morphology ( J:164741 )

• significantly thinner but more compact than that of the wild-type mice

abnormal corneocyte envelope morphology ( J:164741 )

• the density of the cornified cell envelope is only 15-18% of wild-type

dry skin ( J:164741 )

scaly skin ( J:164741 )

abnormal keratinocyte physiology ( J:164741 )

• calcium responses to TRPV3 agonists are impaired