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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cxcr4tm1Yiw
targeted mutation 1, Yoichiro Iwakura
MGI:4836915
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cxcr4tm1Yiw/Cxcr4tm1Yiw
Tg(Lck-cre)1Jtak/0 		involves: 129P2/OlaHsd MGI:4836916


Genotype
MGI:4836916
cn1
Allelic
Composition		 Cxcr4tm1Yiw/Cxcr4tm1Yiw
Tg(Lck-cre)1Jtak/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm1Yiw mutation (5 available); any Cxcr4 mutation (46 available)
Tg(Lck-cre)1Jtak mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal leukocyte migration ( J:164872 )
• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers
decreased thymocyte number ( J:164872 )
• thymocytes numbers are significantly reduced

immune system
abnormal leukocyte migration ( J:164872 )
• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers
decreased thymocyte number ( J:164872 )
• thymocytes numbers are significantly reduced
decreased susceptibility to induced arthritis ( J:164872 )
• the incidence, but not the severity, of collagen induced arthritis is significantly reduced

skeleton
decreased susceptibility to induced arthritis ( J:164872 )
• the incidence, but not the severity, of collagen induced arthritis is significantly reduced

cellular
abnormal leukocyte migration ( J:164872 )
• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers

endocrine/exocrine glands
decreased thymocyte number ( J:164872 )
• thymocytes numbers are significantly reduced




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory