Phenotypes associated with this allele

• Allele Symbol: Smn1^tm1.1Dscd
• Allele Name: targeted mutation 1.1, Dawn S Chandler
• Allele ID: MGI:4836979
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smn1^tm1.1Dscd/Smn1^tm1.1Dscd	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6	MGI:4836985
ht2	Smn1^tm1Msd/Smn1^tm1.1Dscd	involves: 129S/SvEv * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	MGI:4836986

Genotype
MGI:4836985

hm1

• Allelic Composition: Smn1^tm1.1Dscd/Smn1^tm1.1Dscd
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:164889 )

decreased vertical activity ( J:164889 )

• at 60 days

decreased locomotor activity ( J:164889 )

• at 60 days

muscle

increased skeletal muscle fiber size ( J:164889 )

• at 60 days, mice exhibit an increase in larger-sized fibers compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
juvenile spinal muscular atrophy		DOID:12376	OMIM:253400	J:164889

Genotype
MGI:4836986

ht2

• Allelic Composition: Smn1^tm1Msd/Smn1^tm1.1Dscd
• Genetic Background: involves: 129S/SvEv * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

behavior/neurological

decreased grip strength ( J:164889 )

decreased vertical activity ( J:164889 )

• at 60 days

decreased locomotor activity ( J:164889 )

• at 60 days

nervous system

nervous system phenotype ( J:164889 )

N • mice exhibit normal neuromuscular junctions morphology and neuromuscular transmissions