Phenotypes associated with this allele

• Allele Symbol: Mdm2^tm1.1Ypz
• Allele Name: targeted mutation 1.1, Yangping Zhang
• Allele ID: MGI:4836988
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mdm2^tm1.1Ypz/Mdm2^tm1.1Ypz	B6.129-Mdm2^tm1.1Ypz	MGI:4836992
cx2	Mdm2^tm1.1Ypz/Mdm2^tm1.1Ypz Tg(IghMyc)22Bri/0	B6.Cg-Mdm2^tm1.1Ypz Tg(IghMyc)22Bri	MGI:4836993
cx3	Mdm2^tm1.1Ypz/Mdm2^+ Tg(IghMyc)22Bri/0	B6.Cg-Mdm2^tm1.1Ypz Tg(IghMyc)22Bri	MGI:4836994

Genotype
MGI:4836992

hm1

• Allelic Composition: Mdm2^tm1.1Ypz/Mdm2^tm1.1Ypz
• Genetic Background: B6.129-Mdm2^tm1.1Ypz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cell proliferation ( J:164200 )

• of actinomycin D-treated mouse embryonic fibroblasts and keratinocytes

Genotype
MGI:4836993

cx2

• Allelic Composition: Mdm2^tm1.1Ypz/Mdm2^tm1.1Ypz; Tg(IghMyc)22Bri/0
• Genetic Background: B6.Cg-Mdm2^tm1.1Ypz Tg(IghMyc)22Bri

mortality/aging

premature death ( J:164200 )

• median survival is 9 weeks

immune system

enlarged thymus ( J:164200 )

spleen hyperplasia ( J:164200 )

enlarged Peyer's patches ( J:164200 )

enlarged lymph nodes ( J:164200 )

neoplasm

increased lymphoma incidence ( J:164200 )

• lymphomagenesis is accelerated compared to in Tg(IghMyc)22Bri mice

liver/biliary system

enlarged liver ( J:164200 )

hematopoietic system

enlarged thymus ( J:164200 )

spleen hyperplasia ( J:164200 )

endocrine/exocrine glands

enlarged thymus ( J:164200 )

growth/size/body

enlarged liver ( J:164200 )

spleen hyperplasia ( J:164200 )

Genotype
MGI:4836994

cx3

• Allelic Composition: Mdm2^tm1.1Ypz/Mdm2⁺; Tg(IghMyc)22Bri/0
• Genetic Background: B6.Cg-Mdm2^tm1.1Ypz Tg(IghMyc)22Bri

mortality/aging

premature death ( J:164200 )

• median survival is 15 weeks