About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccr10tm1.1Nax
targeted mutation 1.1, Na Xiong
MGI:4837004
Summary 3 genotypes


Genotype
MGI:4837089
hm1
Allelic
Composition		 Ccr10tm1.1Nax/Ccr10tm1.1Nax
Genetic
Background		 B6.129S4(Cg)-Ccr10tm1.1Nax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr10tm1.1Nax mutation (0 available); any Ccr10 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased gamma-delta intraepithelial T cell number ( J:165323 )
• skin intra epidermal gamma/delta T lymphocytes are generated normally
• migration into the epidermis is impaired
• 2.2 fold reduction in levels in the epidermis at 2-3 days of age
• epidermal deficit continues in older mice but is less severe
• abnormal dendritic morphology
• cell levels in the dermis are 3 times higher

hematopoietic system
decreased gamma-delta intraepithelial T cell number ( J:165323 )
• skin intra epidermal gamma/delta T lymphocytes are generated normally
• migration into the epidermis is impaired
• 2.2 fold reduction in levels in the epidermis at 2-3 days of age
• epidermal deficit continues in older mice but is less severe
• abnormal dendritic morphology
• cell levels in the dermis are 3 times higher




Genotype
MGI:7643504
cx2
Allelic
Composition		 Ccl27atm1.1(KOMP)Vlcg/Ccl27atm1.1(KOMP)Vlcg
Ccr10tm1.1Nax/Ccr10+
Genetic
Background		 B6.Cg-Ccl27atm1.1(KOMP)Vlcg Ccr10tm1.1Nax
Cell Lines 14813A-F9
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl27atm1.1(KOMP)Vlcg mutation (1 available); any Ccl27a mutation (13 available)
Ccr10tm1.1Nax mutation (0 available); any Ccr10 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:330550 )
N
• adult mice show no significant differences in the percentages of CCR10(EGFP)+ Treg or other T cell subsets (CD4+, CD8+, and gamma-delta T cells) in skin relative to controls, indicating normal establishment of CCR10+ lymphocytes in adult skin




Genotype
MGI:7643522
cx3
Allelic
Composition		 Ccl27aem1Nax/Ccl27aem1Nax
Ccl27alem1Nax/Ccl27alem1Nax
Ccl27bem1Nax/Ccl27bem1Nax
Ccr10tm1.1Nax/Ccr10+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl27aem1Nax mutation (0 available); any Ccl27a mutation (13 available)
Ccl27alem1Nax mutation (0 available); any Ccl27al mutation (4 available)
Ccl27bem1Nax mutation (0 available); any Ccl27b mutation (0 available)
Ccr10tm1.1Nax mutation (0 available); any Ccr10 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired leukocyte migration ( J:330550 )
• mice show impaired establishment and dysregulated localization of CCR10+ lymphocytes in the skin
• numbers of alpha-beta T cells and percentages of CCR10(EGFP)+ Treg cells, alpha-beta T cells, gamma-delta T cells, and innate lymphoid cells (ILCs) are significantly lower in the skin at 2 weeks of age
• similarly, numbers of alpha-beta T cells and percentages of CCR10(EGFP)+ Treg cells, CD8+ T cells, CD4+ T cells, gamma-delta T cells, and ILCs, are significantly lower in the skin of adult mice
• numbers of CCR10(EGFP)+ CD4+ T cells and CD8+ T cells are significantly reduced in adult skin
• adult mice show a lower percentage of CCR10(EGFP)+ ILCs and T cells localized close to/on the skin hair follicles but a higher percentage localized below hair follicles
• percentages of CCR10(EGFP)+ CD4+ T cells, CD8+ T cells, and ILCs are significantly increased in the blood and spleen of adult mice, suggesting that CCR10+ lymphocytes do not effectively migrate into the skin and instead continue to circulate in the blood and accumulate in the spleen
• percentages of CCR10(EGFP)+ CD4+ and CD8+ alpha-beta T cells are significantly increased in the lungs and uteri of adult mice, whereas frequencies of CCR10(EGFP)+ ILCs and gamma-delta T cells are mildly increased or unchanged in these mucosal tissues
• however, total numbers of skin gamma-delta T cells and ILCs as well as the percentage of CCR10(EGFP)+ gamma-delta T cells in the blood and spleen are not significantly altered
increased interleukin-10 secretion ( J:330550 )
• adult mice show a small (<5%) increase in the percentage of IL-10-expressing skin CD4+ T cells relative to controls
• however, no significant differences are noted in the production of IL-17A or IFN-gamma by total or CCR10(EGFP)+ skin ILCs, CD8 +, CD4+, and gamma-delta T cells
uterus inflammation ( J:330550 )
• some mice show visible signs of spontaneous uterus inflammation

reproductive system
abnormal uterus physiology ( J:330550 )
• uteri show a significant increase in the percentages of CCR10(EGFP)+ CD4+ and CD8+ alpha-beta T cells along with an increase in the absolute number of CD45+ immune cells, indicating immune dysregulation in uterine tissue
uterus inflammation ( J:330550 )
• some mice show visible signs of spontaneous uterus inflammation

cellular
impaired leukocyte migration ( J:330550 )
• mice show impaired establishment and dysregulated localization of CCR10+ lymphocytes in the skin
• numbers of alpha-beta T cells and percentages of CCR10(EGFP)+ Treg cells, alpha-beta T cells, gamma-delta T cells, and innate lymphoid cells (ILCs) are significantly lower in the skin at 2 weeks of age
• similarly, numbers of alpha-beta T cells and percentages of CCR10(EGFP)+ Treg cells, CD8+ T cells, CD4+ T cells, gamma-delta T cells, and ILCs, are significantly lower in the skin of adult mice
• numbers of CCR10(EGFP)+ CD4+ T cells and CD8+ T cells are significantly reduced in adult skin
• adult mice show a lower percentage of CCR10(EGFP)+ ILCs and T cells localized close to/on the skin hair follicles but a higher percentage localized below hair follicles
• percentages of CCR10(EGFP)+ CD4+ T cells, CD8+ T cells, and ILCs are significantly increased in the blood and spleen of adult mice, suggesting that CCR10+ lymphocytes do not effectively migrate into the skin and instead continue to circulate in the blood and accumulate in the spleen
• percentages of CCR10(EGFP)+ CD4+ and CD8+ alpha-beta T cells are significantly increased in the lungs and uteri of adult mice, whereas frequencies of CCR10(EGFP)+ ILCs and gamma-delta T cells are mildly increased or unchanged in these mucosal tissues
• however, total numbers of skin gamma-delta T cells and ILCs as well as the percentage of CCR10(EGFP)+ gamma-delta T cells in the blood and spleen are not significantly altered

hematopoietic system
impaired leukocyte migration ( J:330550 )
• mice show impaired establishment and dysregulated localization of CCR10+ lymphocytes in the skin
• numbers of alpha-beta T cells and percentages of CCR10(EGFP)+ Treg cells, alpha-beta T cells, gamma-delta T cells, and innate lymphoid cells (ILCs) are significantly lower in the skin at 2 weeks of age
• similarly, numbers of alpha-beta T cells and percentages of CCR10(EGFP)+ Treg cells, CD8+ T cells, CD4+ T cells, gamma-delta T cells, and ILCs, are significantly lower in the skin of adult mice
• numbers of CCR10(EGFP)+ CD4+ T cells and CD8+ T cells are significantly reduced in adult skin
• adult mice show a lower percentage of CCR10(EGFP)+ ILCs and T cells localized close to/on the skin hair follicles but a higher percentage localized below hair follicles
• percentages of CCR10(EGFP)+ CD4+ T cells, CD8+ T cells, and ILCs are significantly increased in the blood and spleen of adult mice, suggesting that CCR10+ lymphocytes do not effectively migrate into the skin and instead continue to circulate in the blood and accumulate in the spleen
• percentages of CCR10(EGFP)+ CD4+ and CD8+ alpha-beta T cells are significantly increased in the lungs and uteri of adult mice, whereas frequencies of CCR10(EGFP)+ ILCs and gamma-delta T cells are mildly increased or unchanged in these mucosal tissues
• however, total numbers of skin gamma-delta T cells and ILCs as well as the percentage of CCR10(EGFP)+ gamma-delta T cells in the blood and spleen are not significantly altered




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory