Phenotypes associated with this allele

• Allele Symbol: Rr7^tm1.1Kio
• Allele Name: targeted mutation 1.1, Dimitris Kioussis
• Allele ID: MGI:4837102
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr7^tm1.1Kio/Rr7^tm1.1Kio	involves: 129S4/SvJae * C57BL/6	MGI:4837109

Genotype
MGI:4837109

hm1

• Allelic Composition: Rr7^tm1.1Kio/Rr7^tm1.1Kio
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:164573 )

N • the absolute number of thymocytes and T cell subpopulations as well as the ratio of CD4+ and CD8+ cells are normal

abnormal CD4-positive, alpha beta T cell morphology ( J:164573 , J:179326 )

• unlike in wild-type mice, CD4+ cells express CD8 to a greater extent than Rr7^tm2.1Kio homozygotes (J:164573)

• CD8 expression in CD4 cells decreases with age (J:164573)

• unlike wild-type cells, a portion of peripheral CD4+ T cells expressing CD8 (J:179326)

• however, the number of CD4+(CD8+) decreases with age due to thymus involution (J:179326)

hematopoietic system

abnormal CD4-positive, alpha beta T cell morphology ( J:164573 , J:179326 )

• unlike in wild-type mice, CD4+ cells express CD8 to a greater extent than Rr7^tm2.1Kio homozygotes (J:164573)

• CD8 expression in CD4 cells decreases with age (J:164573)

• unlike wild-type cells, a portion of peripheral CD4+ T cells expressing CD8 (J:179326)

• however, the number of CD4+(CD8+) decreases with age due to thymus involution (J:179326)