Phenotypes associated with this allele

• Allele Symbol: Rr7^tm2.1Kio
• Allele Name: targeted mutation 2.1, Dimitris Kioussis
• Allele ID: MGI:4837105
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr7^tm2.1Kio/Rr7^tm2.1Kio	involves: 129S4/SvJae * C57BL/6	MGI:4837110

Genotype
MGI:4837110

hm1

• Allelic Composition: Rr7^tm2.1Kio/Rr7^tm2.1Kio
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:164573 )

N • the absolute number of thymocytes and T cell subpopulations as well as the ratio of CD4+ and CD8+ cells are normal

abnormal CD4-positive, alpha beta T cell morphology ( J:164573 )

• unlike in wild-type mice, CD4+ cells express CD8 to a lesser extent than Rr7^tm2.1Kio homozygotes

• CD8 expression in CD4 cells decreases with age

hematopoietic system

abnormal CD4-positive, alpha beta T cell morphology ( J:164573 )

• unlike in wild-type mice, CD4+ cells express CD8 to a lesser extent than Rr7^tm2.1Kio homozygotes

• CD8 expression in CD4 cells decreases with age