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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(MMTV-cre)105Ayn
transgene insertion 105, Alexander Yu Nikitin
MGI:4837133
Summary 3 genotypes


Genotype
MGI:4837143
cn1
Allelic
Composition		 Rb1tm2Brn/Rb1tm2Brn
Tg(MMTV-cre)105Ayn/0
Genetic
Background		 FVB.Cg-Rb1tm2Brn Tg(MMTV-cre)105Ayn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (3 available); any Rb1 mutation (111 available)
Tg(MMTV-cre)105Ayn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:165292 )
N
• mice do not develop mammary neoplasms




Genotype
MGI:4837145
cn2
Allelic
Composition		 Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)105Ayn/0
Genetic
Background		 FVB.Cg-Trp53tm1Brn Rb1tm2Brn Tg(MMTV-cre)105Ayn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (3 available); any Rb1 mutation (111 available)
Tg(MMTV-cre)105Ayn mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:165292 )
• 15 of 17 mice develop mammary neoplasms
• mammary tumor cells exhibit increased genomic instability compared to in Trp53tm1Brn/Trp53tm1Brn Tg(MMTV-cre)105Ayn mice
increased tumor growth/size ( J:165292 )
• cell proliferation in mammary carcinomas is increased compared to in Trp53tm1Brn/Trp53tm1Brn Tg(MMTV-cre)105Ayn mice
increased carcinoma incidence ( J:165292 )
• 10 of 43 neoplasms are well-differentiated carcinomas
• while one tumor is an adenosquamous carcinoma the remaining tumors are poorly differentiated carcinomas with spindle or polygonal, frequently pleomorphic cells
increased squamous cell carcinoma incidence ( J:165292 )
• 1 adenosquamous carcinoma
increased lung tumor incidence ( J:165292 )
• 4 of 40 mice develop lung metastasis

cellular
chromosomal instability ( J:165292 )
• mammary tumor cells exhibit increased genomic instability compared to in Trp53tm1Brn/Trp53tm1Brn Tg(MMTV-cre)105Ayn mice

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:165292 )
• 15 of 17 mice develop mammary neoplasms
• mammary tumor cells exhibit increased genomic instability compared to in Trp53tm1Brn/Trp53tm1Brn Tg(MMTV-cre)105Ayn mice

integument
increased mammary gland tumor incidence ( J:165292 )
• 15 of 17 mice develop mammary neoplasms
• mammary tumor cells exhibit increased genomic instability compared to in Trp53tm1Brn/Trp53tm1Brn Tg(MMTV-cre)105Ayn mice

respiratory system
increased lung tumor incidence ( J:165292 )
• 4 of 40 mice develop lung metastasis




Genotype
MGI:4837144
cn3
Allelic
Composition		 Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)105Ayn/0
Genetic
Background		 FVB.Cg-Trp53tm1Brn Tg(MMTV-cre)105Ayn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-cre)105Ayn mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:165292 )
• by 700 days, 8 of 16 mice develop mammary neoplasms
• however, mice do not exhibit lymphomas or other non-mammary neoplasms
increased carcinoma incidence ( J:165292 )
• 8 of 27 neoplasms are well-differentiated carcinomas
• while one tumor is an adenosquamous carcinoma the remaining tumors are poorly differentiated carcinomas with spindle or polygonal, frequently pleomorphic cells
increased squamous cell carcinoma incidence ( J:165292 )
• 1 adenosquamous carcinoma
increased lung tumor incidence ( J:165292 )
• 3 of 27 mice develop lung metastasis

integument
increased mammary gland tumor incidence ( J:165292 )
• by 700 days, 8 of 16 mice develop mammary neoplasms
• however, mice do not exhibit lymphomas or other non-mammary neoplasms

respiratory system
increased lung tumor incidence ( J:165292 )
• 3 of 27 mice develop lung metastasis

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:165292 )
• by 700 days, 8 of 16 mice develop mammary neoplasms
• however, mice do not exhibit lymphomas or other non-mammary neoplasms




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory