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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Paip2tm1.2Nso
targeted mutation 1.2, Nahum Sonenberg
MGI:4837189
Summary 2 genotypes


Genotype
MGI:4837215
hm1
Allelic
Composition		 Paip2tm1.2Nso/Paip2tm1.2Nso
Genetic
Background		 B6.129-Paip2tm1.2Nso
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Paip2tm1.2Nso mutation (0 available); any Paip2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:165272 )
N
• female fertility is normal
abnormal cauda epididymis morphology ( J:165272 )
• aberrant round structures are present in the cauda epididymides unlike in wild-type mice




Genotype
MGI:4837220
cx2
Allelic
Composition		 Paip2tm1.2Nso/Paip2tm1.2Nso
Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic
Background		 B6.129-Paip2btm1.2Nso Paip2tm1.2Nso
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Paip2btm1.2Nso mutation (0 available); any Paip2b mutation (18 available)
Paip2tm1.2Nso mutation (0 available); any Paip2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:165272 )
N
• female fertility is normal
• testes and seminal vesicle weights are normal
teratozoospermia ( J:165272 )
• mice exhibit aberrant spermatozoa in the epithelia along the lumen of seminiferous tubules at stage VII compared with wild-type mice
abnormal sperm nucleus morphology ( J:165272 )
• chromatin condensation is abnormal unlike in wild-type sperm
abnormal spermatid morphology ( J:165272 )
• spermatids contain spherical structures in the cytoplasm and various sized vacuoles in the nuclei unlike in wild-type spermatids
• mice exhibit defective elongated spermatids unlike in wild-type mice
• elongated spermatids are retained even at stages IX-XII unlike in wild-type mice
azoospermia ( J:165272 )
• in some mice
abnormal spermiogenesis ( J:165272 )
• in late spermiogenesis, translation of mRNAs is inhibited unlike in wild-type cells
abnormal cauda epididymis morphology ( J:165272 )
• aberrant round structures are present in the cauda epididymides unlike in wild-type mice

growth/size/body
decreased body weight ( J:165272 )

endocrine/exocrine glands

cellular
teratozoospermia ( J:165272 )
• mice exhibit aberrant spermatozoa in the epithelia along the lumen of seminiferous tubules at stage VII compared with wild-type mice
abnormal sperm nucleus morphology ( J:165272 )
• chromatin condensation is abnormal unlike in wild-type sperm
abnormal spermatid morphology ( J:165272 )
• spermatids contain spherical structures in the cytoplasm and various sized vacuoles in the nuclei unlike in wild-type spermatids
• mice exhibit defective elongated spermatids unlike in wild-type mice
• elongated spermatids are retained even at stages IX-XII unlike in wild-type mice
azoospermia ( J:165272 )
• in some mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory