All Phenotypes Paip2b<tm1.2Nso> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Paip2b^tm1.2Nso
targeted mutation 1.2, Nahum Sonenberg
MGI:4837192

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Paip2b^tm1.2Nso/Paip2b^tm1.2Nso	B6.129-Paip2b^tm1.2Nso	MGI:4837219
cx2	Paip2^tm1.2Nso/Paip2^tm1.2Nso Paip2b^tm1.2Nso/Paip2b^tm1.2Nso	B6.129-Paip2b^tm1.2Nso Paip2^tm1.2Nso	MGI:4837220

Allelic Composition	Paip2b^tm1.2Nso/Paip2b^tm1.2Nso
Genetic Background	B6.129-Paip2b^tm1.2Nso

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Paip2b^tm1.2Nso mutation (0 available); any Paip2b mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:165272 )

N	• mice exhibit normal spermiogenesis

Allelic Composition	Paip2^tm1.2Nso/Paip2^tm1.2Nso Paip2b^tm1.2Nso/Paip2b^tm1.2Nso
Genetic Background	B6.129-Paip2b^tm1.2Nso Paip2^tm1.2Nso

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Paip2b^tm1.2Nso mutation (0 available); any Paip2b mutation (18 available)
Paip2^tm1.2Nso mutation (0 available); any Paip2 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:165272 )

N	• female fertility is normal • testes and seminal vesicle weights are normal

teratozoospermia ( J:165272 )

• mice exhibit aberrant spermatozoa in the epithelia along the lumen of seminiferous tubules at stage VII compared with wild-type mice

absent sperm mitochondrial sheath ( J:165272 )

detached acrosome ( J:165272 )

abnormal sperm nucleus morphology ( J:165272 )

• chromatin condensation is abnormal unlike in wild-type sperm

abnormal spermatid morphology ( J:165272 )

• spermatids contain spherical structures in the cytoplasm and various sized vacuoles in the nuclei unlike in wild-type spermatids

• mice exhibit defective elongated spermatids unlike in wild-type mice

• elongated spermatids are retained even at stages IX-XII unlike in wild-type mice

decreased male germ cell number ( J:165272 )

azoospermia ( J:165272 )

• in some mice

decreased prostate gland weight ( J:165272 )

abnormal spermiogenesis ( J:165272 )

• in late spermiogenesis, translation of mRNAs is inhibited unlike in wild-type cells

abnormal cauda epididymis morphology ( J:165272 )

• aberrant round structures are present in the cauda epididymides unlike in wild-type mice

decreased epididymis weight ( J:165272 )

male infertility ( J:165272 )

growth/size/body

decreased body weight ( J:165272 )

endocrine/exocrine glands

decreased prostate gland weight ( J:165272 )

cellular

teratozoospermia ( J:165272 )

• mice exhibit aberrant spermatozoa in the epithelia along the lumen of seminiferous tubules at stage VII compared with wild-type mice

absent sperm mitochondrial sheath ( J:165272 )

detached acrosome ( J:165272 )

abnormal sperm nucleus morphology ( J:165272 )

• chromatin condensation is abnormal unlike in wild-type sperm

abnormal spermatid morphology ( J:165272 )

• spermatids contain spherical structures in the cytoplasm and various sized vacuoles in the nuclei unlike in wild-type spermatids

• mice exhibit defective elongated spermatids unlike in wild-type mice

• elongated spermatids are retained even at stages IX-XII unlike in wild-type mice

decreased male germ cell number ( J:165272 )

azoospermia ( J:165272 )

• in some mice

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