Phenotypes associated with this allele

• Allele Symbol: Tg(Fev-cre/ERT2)aEsd
• Allele Name: transgene insertion a, Evan S Deneris
• Allele ID: MGI:4837204
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fev^tm1Esd/Fev^tm2Esd Tg(Fev-cre/ERT2)aEsd/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4837216

Genotype
MGI:4837216

cn1

• Allelic Composition: Fev^tm1Esd/Fev^tm2Esd; Tg(Fev-cre/ERT2)aEsd/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased anxiety-related response ( J:165266 )

• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, mice spend less time and make fewer entrances into the open arms of an elevated plus maze

• however, the level of exploratory behavior in the elevated plus maze is normal

• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, mice spend more time in the dark chamber in a light dark exploration assay

increased thigmotaxis ( J:165266 )

• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, mice spend less time in the center of an open field

homeostasis/metabolism

decreased serotonin level ( J:165266 )

• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, brain levels of 5-HT and 5-HIAA are significantly decreased