Phenotypes associated with this allele

• Allele Symbol: Maf1^tm1.1Lnh
• Allele Name: targeted mutation 1.1, Nouria Hernandez
• Allele ID: MGI:4837337
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Maf1^tm1.1Lnh/Maf1^tm1.1Lnh	involves: C57BL/6	MGI:5690251

Genotype
MGI:5690251

hm1

• Allelic Composition: Maf1^tm1.1Lnh/Maf1^tm1.1Lnh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased subcutaneous adipose tissue amount ( J:222253 )

• mice exhibit little subcutaneous adipose tissue on high fat diet as compared to controls

increased white fat cell number ( J:222253 )

• chow-fed mice have twice the number of adipocytes in the epididymal fat pad

decreased white fat cell size ( J:222253 )

• reduced epididymal WAT cell volume on both high and low fat diets

decreased epididymal fat pad weight ( J:222253 )

• reduced size of epididymal fat pads

decreased omental fat pad weight ( J:222253 )

• mice exhibit little omental adipose tissue on high fat diet as compared to controls

decreased percent body fat/body weight ( J:222253 )

• on a chow-fed diet as compared to controls

growth/size/body

decreased lean body mass ( J:222253 )

• in mice older than 6 months as compared to controls

decreased body length ( J:222253 )

• decreased body length is observed in mice older than 6 months as compared to controls

decreased susceptibility to diet-induced obesity ( J:222253 )

• mice do not gain body weight at same rate as controls when fed ad libitum high fat diet

• mice exhibit an increase in percentage of body fat after 8 weeks on high fat diet, but increase is significantly less than controls

• adipocytes do not become hypertrophic on high fat diet

• less fat as a percentage of body weight on high fat diet as compared to control

postnatal growth retardation ( J:222253 )

• overall reduction in growth rate

slow postnatal weight gain ( J:222253 )

• mice appear normal at birth, but exhibit a lower body weight at weaning as compared to controls

• high fat diet does not improve weight gain

behavior/neurological

decreased food intake ( J:222253 )

• reduction in food intake (chow fed) as compared to controls

homeostasis/metabolism

abnormal homeostasis ( J:222253 )

• increased levels of the polyamine pathway metabolites ornithine, putrescine and spermidine

abnormal amino acid level ( J:222253 )

• skeletal tissues have elevated levels of alanine, arginine, asparagine, histidine, isoleucine, methionine, phenylalanine, proline, threonine, tryptophan, and valine

• liver tissues have elevated levels of asparagine, isoleucine, lysine proline, serine, threonine, and valine

increased proline level ( J:222253 )

• in skeletal tissues

increased dopamine level ( J:222253 )

increased energy expenditure ( J:222253 )

• increase in energy expenditure on high fat diet as compared to controls

• difference is greater at night than during active period

decreased susceptibility to diet-induced obesity ( J:222253 )

• mice do not gain body weight at same rate as controls when fed ad libitum high fat diet

• mice exhibit an increase in percentage of body fat after 8 weeks on high fat diet, but increase is significantly less than controls

• adipocytes do not become hypertrophic on high fat diet

• less fat as a percentage of body weight on high fat diet as compared to control

increased oxygen consumption ( J:222253 )

• increase in oxygen consumption on high fat diet as compared to controls

increased insulin sensitivity ( J:222253 )

abnormal lipid homeostasis ( J:222253 )

• ncreased in de novo lipogenesis is observed in livers from chow fed mice as compared to controls

decreased circulating phospholipid level ( J:222253 )

• reduced levels of multiple glycerophospholipids in plasma

increased hormone-sensitive lipase activity ( J:222253 )

• level of activated hormone sensitive lipase is fourfold higher in epididymal WAT of chow-fed mice

integument

decreased subcutaneous adipose tissue amount ( J:222253 )

• mice exhibit little subcutaneous adipose tissue on high fat diet as compared to controls

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:222253 )

• mice on high fat diet do not exhibit lipid droplet accumulation in the liver

mortality/aging

extended life span ( J:222253 )

• extension of mean and maximal lifespan as compared to controls

reproductive system

reduced fertility ( J:222253 )

• reduced fertility

• reduced fecundity