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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nbr1tm1.1Jmos
targeted mutation 1.1, Jorge Moscat
MGI:4837426
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Nbr1tm1.1Jmos/Nbr1tm1.1Jmos
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129X1/SvJ * C57BL/6J MGI:4837529


Genotype
MGI:4837529
cn1
Allelic
Composition
Nbr1tm1.1Jmos/Nbr1tm1.1Jmos
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbr1tm1.1Jmos mutation (0 available); any Nbr1 mutation (74 available)
Tnfrsf4tm2(cre)Nik mutation (1 available); any Tnfrsf4 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in Th1-polarized T cells, IFN-gamma secretion is mildly, if at all, affected compared with similarly treated wild-type cells
• Th2-polarized T cell exhibit impaired IL4 and IL5 secretion compared with similarly treated wild-type cells
• slightly, but not significantly, in CD4+ T cells stimulated with anti-CD3 and anti-CD28 antibodies
• from anti-CD3- and anti-CD28-stimulated CD4+ T cells
• in the bronchoalveolar lavage fluid from ovalbumin challenged mice
• from anti-CD3- and anti-CD28-stimulated CD4+ T cells
• in Th2-polarized T cells
• in the bronchoalveolar lavage fluid from ovalbumin challenged mice
• in Th2-polarized T cells
• in the bronchoalveolar lavage fluid from ovalbumin challenged mice
• following ovalbumin challenge, mice exhibit reduced inflammation (bronchoalveolar lavage total cell number, eosinophil infiltration, and levels of IL4, IL5, and IL13) compared with similarly treated wild-type mice

hematopoietic system
• in Th1-polarized T cells, IFN-gamma secretion is mildly, if at all, affected compared with similarly treated wild-type cells
• Th2-polarized T cell exhibit impaired IL4 and IL5 secretion compared with similarly treated wild-type cells





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory