immune system
• in Th1-polarized T cells, IFN-gamma secretion is mildly, if at all, affected compared with similarly treated wild-type cells
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• Th2-polarized T cell exhibit impaired IL4 and IL5 secretion compared with similarly treated wild-type cells
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• slightly, but not significantly, in CD4+ T cells stimulated with anti-CD3 and anti-CD28 antibodies
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• from anti-CD3- and anti-CD28-stimulated CD4+ T cells
• in the bronchoalveolar lavage fluid from ovalbumin challenged mice
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• from anti-CD3- and anti-CD28-stimulated CD4+ T cells
• in Th2-polarized T cells
• in the bronchoalveolar lavage fluid from ovalbumin challenged mice
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• in Th2-polarized T cells
• in the bronchoalveolar lavage fluid from ovalbumin challenged mice
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• following ovalbumin challenge, mice exhibit reduced inflammation (bronchoalveolar lavage total cell number, eosinophil infiltration, and levels of IL4, IL5, and IL13) compared with similarly treated wild-type mice
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hematopoietic system
• in Th1-polarized T cells, IFN-gamma secretion is mildly, if at all, affected compared with similarly treated wild-type cells
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• Th2-polarized T cell exhibit impaired IL4 and IL5 secretion compared with similarly treated wild-type cells
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