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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr8tm1Vlcg
targeted mutation 1, Velocigene
MGI:4837530
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr8tm1Vlcg/Tlr8tm1Vlcg B6.129S1-Tlr8tm1Vlcg MGI:4837536
cx2
 		Tlr8/Tlr7tm1Vlcg/Tlr7+
Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg 		B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg MGI:4837539


Genotype
MGI:4837536
hm1
Allelic
Composition		 Tlr8tm1Vlcg/Tlr8tm1Vlcg
Genetic
Background		 B6.129S1-Tlr8tm1Vlcg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr8tm1Vlcg mutation (0 available); any Tlr8 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:165267 )
• with expansion of the CD11c+ and CD19+ populations but decrease in dendritic cell and marginal zone B cells
decreased marginal zone B cell number ( J:165267 )
• peripheral to follicles
increased IgG level ( J:165267 )
• as glomerular deposition, but not in the serum
increased IgM level ( J:165267 )
• in the serum and as glomerular deposition
increased circulating interleukin-12 level ( J:165267 )
• in bone marrow-derived dendritic cells, total splenocytes, and splenic dendritic cells stimulated with R848, polyA:U, and any TLR7 ligand tested secrete more IL12b (IL-12p40) than similarly treated wild-type cells
• however, response to pCpG, polyI:C, and LPS is normal and serum level in R848-treated mice is normal
increased interleukin-6 secretion ( J:165267 )
• in bone marrow-derived dendritic cells, total splenocytes, and splenic dendritic cells stimulated with R848, polyA:U, and any TLR7 ligand tested
• however, response to polyI:C and LPS is normal and serum level in R848-treated mice is normal
increased anti-nuclear antigen antibody level ( J:165267 )
• mice exhibit an increase in IgG autoantibodies smRNP, RNP, and dsDNA compared with wild-type mice
glomerulonephritis ( J:165267 )
• mice exhibit increased deposition of IgM, IgG, and C3 in the glomerulus compared with wild-type mice

renal/urinary system
glomerulonephritis ( J:165267 )
• mice exhibit increased deposition of IgM, IgG, and C3 in the glomerulus compared with wild-type mice

homeostasis/metabolism
increased circulating interleukin-12 level ( J:165267 )
• in bone marrow-derived dendritic cells, total splenocytes, and splenic dendritic cells stimulated with R848, polyA:U, and any TLR7 ligand tested secrete more IL12b (IL-12p40) than similarly treated wild-type cells
• however, response to pCpG, polyI:C, and LPS is normal and serum level in R848-treated mice is normal

hematopoietic system
enlarged spleen ( J:165267 )
• with expansion of the CD11c+ and CD19+ populations but decrease in dendritic cell and marginal zone B cells
decreased marginal zone B cell number ( J:165267 )
• peripheral to follicles
increased IgG level ( J:165267 )
• as glomerular deposition, but not in the serum
increased IgM level ( J:165267 )
• in the serum and as glomerular deposition

growth/size/body
enlarged spleen ( J:165267 )
• with expansion of the CD11c+ and CD19+ populations but decrease in dendritic cell and marginal zone B cells
increased spleen weight ( J:165267 )




Genotype
MGI:4837539
cx2
Allelic
Composition		 Tlr8/Tlr7tm1Vlcg/Tlr7+
Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic
Background		 B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr8/Tlr7tm1Vlcg mutation (0 available); any Tlr8 mutation (10 available)
Tlr8/Tlr7tm1Vlcg mutation (0 available); any Tlr7 mutation (20 available)
Tlr8tm1Vlcg mutation (0 available); any Tlr8 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal spleen marginal zone morphology ( J:165267 )
• mice exhibit an intermediate marginal zone phenotype compared with Tlr8tm1Vlcg and double homozygotes
decreased marginal zone B cell number ( J:165267 )
• 2 times lower than in double homozygotes
increased marginal zone B cell number ( J:165267 )
• 2 times higher than in Tlr8tm1Vlcg homozygotes
decreased IgG level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes
increased IgG level ( J:165267 )
• compared with double homozygotes
decreased IgM level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes
increased IgM level ( J:165267 )
• compared with double homozygotes
decreased anti-insulin autoantibody level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes

hematopoietic system
abnormal spleen marginal zone morphology ( J:165267 )
• mice exhibit an intermediate marginal zone phenotype compared with Tlr8tm1Vlcg and double homozygotes
decreased marginal zone B cell number ( J:165267 )
• 2 times lower than in double homozygotes
increased marginal zone B cell number ( J:165267 )
• 2 times higher than in Tlr8tm1Vlcg homozygotes
decreased IgG level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes
increased IgG level ( J:165267 )
• compared with double homozygotes
decreased IgM level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes
increased IgM level ( J:165267 )
• compared with double homozygotes




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory