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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Serpinb2tm2Dgi
targeted mutation 2, David Ginsburg
MGI:4837545
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Serpinb2tm2Dgi/Serpinb2tm2Dgi involves: 129S2/SvPas * C57BL/6J * DBA/2J MGI:4837625
cx2
 		Irs1smla/Irs1smla
Serpinb2tm2Dgi/Serpinb2tm2Dgi 		involves: 129S2/SvPas * C57BL/6J * DBA/2J MGI:4837626
cx3
 		Serpinb2tm2Dgi/Serpinb2tm2Dgi
Serpine1tm1Mlg/Serpine1tm1Mlg 		involves: 129S2/SvPas * C57BL/6J * DBA/2J MGI:4837627


Genotype
MGI:4837625
hm1
Allelic
Composition		 Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpinb2tm2Dgi mutation (0 available); any Serpinb2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:52283 )
• decreased platelet count of marginal significance
abnormal leukocyte cell number ( J:52283 )
• a marginally significant decrease in leukocyte count involving lymphocytes, neutrophils, and monocytes

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:52283 )
N
• mice exhibit normal wound healing

immune system
immune system phenotype ( J:52283 )
N
• mice exhibit normal response to bacterial infectious challenge or endotoxin infusion
abnormal leukocyte cell number ( J:52283 )
• a marginally significant decrease in leukocyte count involving lymphocytes, neutrophils, and monocytes




Genotype
MGI:4837626
cx2
Allelic
Composition		 Irs1smla/Irs1smla
Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1smla mutation (1 available); any Irs1 mutation (52 available)
Serpinb2tm2Dgi mutation (0 available); any Serpinb2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:164568 )
• mice begin to die shortly after weaning
postnatal lethality ( J:164568 )
• mice exhibit a trend towards reduced numbers at weaning

growth/size/body
decreased birth body size ( J:164568 )
decreased body size ( J:52283 , J:164568 )
• at birth, at 2 weeks, and in adult mice (J:164568)
decreased body weight ( J:164568 )
decreased body height ( J:164568 )
• mice exhibit proportional decrease in stature unlike wild-type mice

muscle




Genotype
MGI:4837627
cx3
Allelic
Composition		 Serpinb2tm2Dgi/Serpinb2tm2Dgi
Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpinb2tm2Dgi mutation (0 available); any Serpinb2 mutation (32 available)
Serpine1tm1Mlg mutation (3 available); any Serpine1 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:52283 )
N
• mice exhibit normal wound healing




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory