Phenotypes associated with this allele

• Allele Symbol: Irs1^smla
• Allele Name: small phenotype
• Allele ID: MGI:4837622
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irs1^smla/Irs1^smla	involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6	MGI:4837630
hm2	Irs1^smla/Irs1^smla	involves: 129S2/SvPas * C57BL/6J	MGI:4837629
cx3	Irs1^smla/Irs1^smla Serpinb2^tm2Dgi/Serpinb2^tm2Dgi	involves: 129S2/SvPas * C57BL/6J * DBA/2J	MGI:4837626

Genotype
MGI:4837630

hm1

• Allelic Composition: Irs1^smla/Irs1^smla
• Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:164568 )

N • Background Sensitivity: postnatal survival is normal unlike mice backcrossed to C57BL/6J

Genotype
MGI:4837629

hm2

• Allelic Composition: Irs1^smla/Irs1^smla
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

mortality/aging

premature death ( J:164568 )

• mice exhibit decreased long term survival

postnatal lethality ( J:164568 )

• Background Sensitivity: mice further backcrossed to C57BL/6J (N3-N4) exhibit less than 2% survival at 2 weeks of age unlike mice backcrossed to 129S1/SvImJ

growth/size/body

decreased body size ( J:164568 )

Genotype
MGI:4837626

cx3

• Allelic Composition: Irs1^smla/Irs1^smla; Serpinb2^tm2Dgi/Serpinb2^tm2Dgi
• Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

mortality/aging

premature death ( J:164568 )

• mice begin to die shortly after weaning

postnatal lethality ( J:164568 )

• mice exhibit a trend towards reduced numbers at weaning

growth/size/body

decreased birth body size ( J:164568 )

decreased body size ( J:52283 , J:164568 )

• at birth, at 2 weeks, and in adult mice (J:164568)

decreased body weight ( J:164568 )

decreased body height ( J:164568 )

• mice exhibit proportional decrease in stature unlike wild-type mice

muscle

muscular atrophy ( J:164568 )