Phenotypes associated with this allele

• Allele Symbol: Mir33^tm1.1Koho
• Allele Name: targeted mutation 1.1, Koh Ono
• Allele ID: MGI:4837623
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir33^tm1.1Koho/Mir33^tm1.1Koho	involves: C57BL/6	MGI:4837624

Genotype
MGI:4837624

hm1

• Allelic Composition: Mir33^tm1.1Koho/Mir33^tm1.1Koho
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal cholesterol homeostasis ( J:165420 )

• increase in APOA1 mediated cholesterol efflux in peritoneal macrophages

increased circulating cholesterol level ( J:165420 )

• increase in total cholesterol at 16 weeks of age

increased circulating HDL cholesterol level ( J:165420 )

• at 16 weeks of age

• increase is more prominent in females than in males

• increased levels of HDL are mainly composed of mature HDL (very large, large, and medium HDL)

immune system

abnormal macrophage physiology ( J:165420 )

• increase in APOA1 mediated cholesterol efflux in peritoneal macrophages

hematopoietic system

abnormal macrophage physiology ( J:165420 )

• increase in APOA1 mediated cholesterol efflux in peritoneal macrophages