Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Cryaa-NCOA6*)AD5Cve transgene insertion AD5, Ales Cvekl MGI:4837697 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• eye size is increased compared to in Tg(Cryaa-NCOA6*)AD5Cve mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the number of double strand break positive nuclei in the lenses is reduced 60% compared to in Tg(Cryaa-NCOA6*)AD5Cve mice
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• 1.35- to 1.65-fold compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lens phenotype is more severe than in Tg(Cryaa-NCOA6*)AD9Cve mice
• the organelle-free zone at the center is absent unlike in wild-type mice
• the lens is filled with fibers containing nuclei unlike in wild-type mice
• lens deterioration is accompanied by posterior shift of the transitional zone, swollen and shortened fiber cell length, rounded end fragments, and cortical liquefaction unlike in wild-type mice
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• at E12.5, mice exhibit a posterior shift of some nuclei in the lens unlike in wild-type mice
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• at E15.5, mice exhibit some irregular lens fiber cells containing nuclei with abnormal morphology compared with wild-type mice
• fiber cells are expanded and skewed unlike in wild-type mice
• lens fibers lack the ball-and-socket structures found in wild-type mice
• embryonic and neonatal fiber cells contain more double-strand breaks than in wild-type mice
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• 3.84- to 4.75-fold
• in neonates and more pronounced at P21
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• lenses exhibit apoptosis unlike in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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