Phenotypes associated with this allele

• Allele Symbol: Fadd^tm2.1Wnt
• Allele Name: targeted mutation 2.1, Astar Winoto
• Allele ID: MGI:4837702
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fadd^tm2.1Wnt/Fadd^tm2.1Wnt Tg(Cd4-cre)1Cwi/?	B6.Cg-Tg(Cd4-cre)1Cwi Fadd^tm2.1Wnt	MGI:4837733

Genotype
MGI:4837733

cn1

• Allelic Composition: Fadd^tm2.1Wnt/Fadd^tm2.1Wnt; Tg(Cd4-cre)1Cwi/?
• Genetic Background: B6.Cg-Tg(Cd4-cre)1Cwi Fadd^tm2.1Wnt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal thymocyte apoptosis ( J:162312 )

• mutant thymocytes are resistant to Fas-induced apoptosis

abnormal T cell proliferation ( J:162312 )

• mutant T cells have impaired early cell cycle transition

• mutant T cells exhibit a slower cell cycle kinetic and do not accumulate in culture due to cell death by necrosis during proliferation

enlarged spleen ( J:162312 )

• mutant mice consistently possess elongated lymphnodes and spleen

abnormal erythrocyte cell number ( J:162312 )

• an increase of TER-119+ red blood cells in the spleen but not in the bone marrow

increased B cell number ( J:162312 )

• a drastic increase of B cells in the lymph nodes and spleen

• absolute number of B cells is higher in mutant mice that exhibit splenomegaly

abnormal T cell subpopulation ratio ( J:162312 )

• the percentage of T cells in the peripheral organs of mutant mice is reduced

• the absolute cell number of CD4+ and CD8+ T cells is equal to controls

immune system

abnormal thymocyte apoptosis ( J:162312 )

• mutant thymocytes are resistant to Fas-induced apoptosis

abnormal T cell proliferation ( J:162312 )

• mutant T cells have impaired early cell cycle transition

• mutant T cells exhibit a slower cell cycle kinetic and do not accumulate in culture due to cell death by necrosis during proliferation

enlarged spleen ( J:162312 )

• mutant mice consistently possess elongated lymphnodes and spleen

increased B cell number ( J:162312 )

• a drastic increase of B cells in the lymph nodes and spleen

• absolute number of B cells is higher in mutant mice that exhibit splenomegaly

abnormal T cell subpopulation ratio ( J:162312 )

• the percentage of T cells in the peripheral organs of mutant mice is reduced

• the absolute cell number of CD4+ and CD8+ T cells is equal to controls

enlarged lymph nodes ( J:162312 )

• mutant mice consistently possess elongated lymphnodes and spleen

increased susceptibility to parasitic infection ( J:162312 )

• mutant mice are more susceptible to Toxoplasma gondii infection

• born at the expected Mendelian ratios and appear healthy with no gross abnormalities

cellular

abnormal thymocyte apoptosis ( J:162312 )

• mutant thymocytes are resistant to Fas-induced apoptosis

abnormal T cell proliferation ( J:162312 )

• mutant T cells have impaired early cell cycle transition

• mutant T cells exhibit a slower cell cycle kinetic and do not accumulate in culture due to cell death by necrosis during proliferation

endocrine/exocrine glands

abnormal thymocyte apoptosis ( J:162312 )

• mutant thymocytes are resistant to Fas-induced apoptosis

growth/size/body

enlarged spleen ( J:162312 )

• mutant mice consistently possess elongated lymphnodes and spleen