All Phenotypes Tg(Pdgfra-cre)1Clc MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Pdgfra-cre)1Clc
transgene insertion 1, Constance L Cepko
MGI:4837746

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Senp1^tm1Wami/Senp1^tm1Wami Tg(Pdgfra-cre)1Clc/0	B6.Cg-Senp1^tm1Wami Tg(Pdgfra-cre)1Clc	MGI:5707772
cn2	Crb2^tm1.1Wij/Crb2^tm1.1Wij Tg(Pdgfra-cre)1Clc/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:5586709
cn3	Igs1^{tm11(CAG-Bgeo,-Edn2)Nat}/Igs1⁺ Tg(Pdgfra-cre)1Clc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5544087
cn4	Bbs1^tm2Vcs/Bbs1^tm2Vcs Tg(Pdgfra-cre)1Clc/0	involves: 129S6/SvEvTac * C57BL/6	MGI:5474570
cn5	Acvr1^tm1Glh/Acvr1⁺ Gt(ROSA)26Sor^{tm1.2(CAG-EGFP)Glh}/Gt(ROSA)26Sor⁺ Tg(Pdgfra-cre)1Clc/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * FVB/N	MGI:7278773
cn6	Ephx2^tm1.1Arte/Ephx2^tm1.1Arte Tg(Pdgfra-cre)1Clc/0	involves: C57BL/6	MGI:5609318

Allelic Composition	Senp1^tm1Wami/Senp1^tm1Wami Tg(Pdgfra-cre)1Clc/0
Genetic Background	B6.Cg-Senp1^tm1Wami Tg(Pdgfra-cre)1Clc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Senp1^tm1Wami mutation (0 available); any Senp1 mutation (69 available)
Tg(Pdgfra-cre)1Clc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:228009 )

• age-dependent increase in glucose levels, with an early onset of diabetes at 6 weeks of age

• increase in glucose levels is seen with or without fasting

growth/size/body

decreased body weight ( J:228009 )

• lower body weight after onset of diabetes

endocrine/exocrine glands

abnormal pancreatic islet cell apoptosis ( J:228009 )

• increase in apoptosis of beta cells

abnormal pancreatic islet morphology ( J:228009 )

• structures of pancreatic islets are disrupted, with increased apoptosis of beta cells after onset of diabetes and more severe at later stages

abnormal pancreatic beta cell physiology ( J:228009 )

• increase in apoptosis of beta cells after onset of diabetes and more severe at later stages

cellular

abnormal pancreatic islet cell apoptosis ( J:228009 )

• increase in apoptosis of beta cells

Allelic Composition	Crb2^tm1.1Wij/Crb2^tm1.1Wij Tg(Pdgfra-cre)1Clc/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crb2^tm1.1Wij mutation (0 available); any Crb2 mutation (53 available)
Tg(Pdgfra-cre)1Clc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:210675 )

• mice are born at a 5-fold reduced ratio than expected

vision/eye

abnormal retina layer morphology ( J:210675 )

• protrusion of photoreceptor nuclei into the subretinal space at sites of outer limiting membrane disruption at 5 months of age

• however, 5 month old mice show normal electroretinography (ERG), scanning laser ophthalmoscopy, and spectral domain optical coherence tomography readings

abnormal retina outer nuclear layer morphology ( J:210675 )

• ectopic Muller glial cell nuclei in the outer nuclear layer and activated Muller glial cells are seen at 5 months of age

thin retina outer nuclear layer ( J:210675 )

• at 5 months of age, a reduction of the outer nuclear layer thickness is seen

abnormal retina outer limiting membrane morphology ( J:210675 )

• disruptions of the outer limiting membrane at the periphery of the retina, where rows of photoreceptor nuclei protrude into the subretinal space, are seen at 1, 3, and 5 months of age

Allelic Composition	Igs1^{tm11(CAG-Bgeo,-Edn2)Nat}/Igs1⁺ Tg(Pdgfra-cre)1Clc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs1^{tm11(CAG-Bgeo,-Edn2)Nat} mutation (1 available); any Igs1 mutation (10 available)
Tg(Pdgfra-cre)1Clc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Interstitial tip cells in adult Igs1^{tm11(CAG-Bgeo,-Edn2)Nat}/Igs1⁺ Tg(Pdgfra-cre)1Clc/0 retinas

vision/eye

abnormal retina vasculature morphology ( J:201133 )

• intraretinal capillaries are larger and more numerous; however a large number of these terminate with blind endings

• blind endings are most numerous in the inner plexiform layer and are typically decorated with multiple filopodia

cardiovascular system

abnormal retina vasculature morphology ( J:201133 )

• intraretinal capillaries are larger and more numerous; however a large number of these terminate with blind endings

• blind endings are most numerous in the inner plexiform layer and are typically decorated with multiple filopodia

Allelic Composition	Bbs1^tm2Vcs/Bbs1^tm2Vcs Tg(Pdgfra-cre)1Clc/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bbs1^tm2Vcs mutation (0 available); any Bbs1 mutation (71 available)
Tg(Pdgfra-cre)1Clc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:194096 )

N	• motile cilia in the lateral ventricles are normal

increased neuron apoptosis ( J:194096 )

• 2-fold

decreased neuronal precursor proliferation ( J:194096 )

• reduced 50%

hydrocephaly ( J:194096 )

• non-obstructive beginning at P3

cellular

increased neuron apoptosis ( J:194096 )

• 2-fold

decreased neuronal precursor proliferation ( J:194096 )

• reduced 50%

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Bardet-Biedl syndrome 1		DOID:0110123	OMIM:209900	J:194096

Allelic Composition	Acvr1^tm1Glh/Acvr1⁺ Gt(ROSA)26Sor^{tm1.2(CAG-EGFP)Glh}/Gt(ROSA)26Sor⁺ Tg(Pdgfra-cre)1Clc/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1^tm1Glh mutation (0 available); any Acvr1 mutation (44 available)
Gt(ROSA)26Sor^{tm1.2(CAG-EGFP)Glh} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Pdgfra-cre)1Clc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal response to injury ( J:257905 )

• skeletal muscle exhibits pinch injury-induced heterotopic ossification

skeleton

increased bone ossification ( J:257905 )

• spontaneous heterotopic ossification is seen infrequently in some 2-week-old mice and is present in all 4-week-old mice and extensive in all surviving mice by 6 weeks of age

• heterotopic ossification is seen in the musculature, tendons, and ligaments at diverse locations

• skeletal elements resulting from spontaneous heterotopic ossification are derived almost exclusively from recombined cells

• all mice treated with an anti-activin A mAb prior to onset of heterotopic ossification for 4 weeks survive to 6 weeks of age and 8 of 9 mice show no evidence of heterotopic ossification and no spontaneous heterotopic ossification is not seen in treated 16-week-old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
fibrodysplasia ossificans progressiva		DOID:13374	OMIM:135100	J:257905

Allelic Composition	Ephx2^tm1.1Arte/Ephx2^tm1.1Arte Tg(Pdgfra-cre)1Clc/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephx2^tm1.1Arte mutation (0 available); any Ephx2 mutation (39 available)
Tg(Pdgfra-cre)1Clc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:208344 )

• significant delay in the radial extension of the vascular plexus from the optic nerve to the periphery and decrease in the number of tip cells and filopodia

abnormal vascular branching morphogenesis ( J:208344 )

• significant delay in the radial extension of the vascular plexus from the optic nerve to the periphery and decrease in the number of tip cells and filopodia

vision/eye

abnormal retina vasculature morphology ( J:208344 )

• significant delay in the radial extension of the vascular plexus from the optic nerve to the periphery and decrease in the number of tip cells and filopodia

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