Phenotypes associated with this allele

• Allele Symbol: Gata2^tm3.1Sho
• Allele Name: targeted mutation 3.1, Stuart Orkin
• Allele ID: MGI:4837902
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata2^tm3.1Sho/Gata2^tm3.1Sho	B6.129S1-Gata2^tm3.1Sho	MGI:4837919
hm2	Gata2^tm3.1Sho/Gata2^tm3.1Sho	involves: 129S1/Sv	MGI:5014801

Genotype
MGI:4837919

hm1

• Allelic Composition: Gata2^tm3.1Sho/Gata2^tm3.1Sho
• Genetic Background: B6.129S1-Gata2^tm3.1Sho

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal stress erythropoiesis ( J:165427 )

• mice exhibit defective stress erythropoiesis compared with wild-type mice

anemia ( J:165427 )

• phenylhydrazine-treated mice exhibit peripheral anemia compared with similarly treated wild-type mice

• however, mice recover from acute anemia

decreased erythroid progenitor cell number ( J:165427 )

• the number of stage IV enucleated erythroid progenitor cell is decreased greater than 2-fold compared with wild-type mice

increased erythroid progenitor cell number ( J:165427 )

• at E12.5, stage III erythroid progenitor cell numbers are increased compared with wild-type mice

Genotype
MGI:5014801

hm2

• Allelic Composition: Gata2^tm3.1Sho/Gata2^tm3.1Sho
• Genetic Background: involves: 129S1/Sv

hematopoietic system

hematopoietic system phenotype ( J:173274 )

N • mice exhibit normal hematopoiesis