Phenotypes associated with this allele

• Allele Symbol: Cyp2a5^tm1Ding
• Allele Name: targeted mutation 1, Xinxin Ding
• Allele ID: MGI:4837923
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp2a5^tm1Ding/Cyp2a5^tm1Ding	involves: C57BL/6 * C57BL/6J	MGI:4838063

Genotype
MGI:4838063

hm1

• Allelic Composition: Cyp2a5^tm1Ding/Cyp2a5^tm1Ding
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:165695 )

N • mice exhibit normal levels of testosterone or progesterone

abnormal xenobiotic pharmacokinetics ( J:165695 )

• mice exhibit slower clearance of nicotine with an increase in maximal concentration (3.2-fold at 1 mg/kg, 3.4-fold at 5mg/kg), area under the curve (6.1-fold at 1 mg/kg, 2.7-fold at 5mg/kg), t-half value (2.8-fold at 1 mg/kg, 1.4-fold at 5 mg/kg), and nicotine levels in the liver (2.3-fold) and brain (2.7-fold) compared with wild-type mice

• tissue to plasma abundance ratio of nicotine is decreased compared to in wild-type mice

• mice exhibit reduced cotinine clearance with an increase in area under the curve (2- to 4-fold at 1 mg/kg) and Cmax (1.3-fold) while cotinine levels are decreased in the liver and brain compared with wild-type mice

• rates of cotinine formation are lower in liver microsomes compared to in wild-type mice