Phenotypes associated with this allele

• Allele Symbol: Klf13^tm1Coll
• Allele Name: targeted mutation 1, William Colledge
• Allele ID: MGI:4837928
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf13^tm1Coll/Klf13^tm1Coll	involves: 129S/SvEv	MGI:4843546

Genotype
MGI:4843546

hm1

• Allelic Composition: Klf13^tm1Coll/Klf13^tm1Coll
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:136545 )

• 1.5 times

spleen hyperplasia ( J:136545 )

• 7-fold increase in CD45^med cells in the spleen

• 3-fold increase in CD45- cells in the spleen

• however, the number of CD45^hi cells is normal

abnormal erythropoiesis ( J:136545 )

• spleens exhibit an increased in immature erythroblasts compared to in wild-type mice

• increased cyclin B expression in erythroid cells indicates an increase in cell proliferation compared to in wild-type cells

• however, erythropoiesis in the bone marrows is normal

increased erythroid progenitor cell number ( J:136545 )

• in the spleen

decreased erythrocyte cell number ( J:136545 )

increased mean corpuscular hemoglobin ( J:136545 )

increased mean corpuscular volume ( J:136545 )

increased red blood cell distribution width ( J:136545 )

decreased leukocyte cell number ( J:136545 )

decreased lymphocyte cell number ( J:136545 )

immune system

enlarged spleen ( J:136545 )

• 1.5 times

spleen hyperplasia ( J:136545 )

• 7-fold increase in CD45^med cells in the spleen

• 3-fold increase in CD45- cells in the spleen

• however, the number of CD45^hi cells is normal

decreased leukocyte cell number ( J:136545 )

decreased lymphocyte cell number ( J:136545 )

growth/size/body

enlarged spleen ( J:136545 )

• 1.5 times

spleen hyperplasia ( J:136545 )

• 7-fold increase in CD45^med cells in the spleen

• 3-fold increase in CD45- cells in the spleen

• however, the number of CD45^hi cells is normal