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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rasgrp1m1Anu
mutation 1, Australian National University
MGI:4838027
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rasgrp1m1Anu/Rasgrp1m1Anu C57BL/6JSfdAnu-Rasgrp1m1Anu MGI:5564911
hm2
 		Rasgrp1m1Anu/Rasgrp1m1Anu involves: C57BL/6JSfdAnu * CBA/J MGI:5565188
ht3
 		Rasgrp1m1Anu/Rasgrp1+ involves: C57BL/6JSfdAnu * CBA/J MGI:5565187
cx4
 		Mtorchino/Mtorchino
Rasgrp1m1Anu/Rasgrp1m1Anu 		involves: C57BL/6JAnu * C57BL/6JSfdAnu * CBA/J MGI:5565189
cx5
 		Cd79am1Anu/Cd79am1Anu
Rasgrp1m1Anu/Rasgrp1m1Anu 		involves: C57BL/6JSfdAnu * CBA/J MGI:5565190


Genotype
MGI:5564911
hm1
Allelic
Composition		 Rasgrp1m1Anu/Rasgrp1m1Anu
Genetic
Background		 C57BL/6JSfdAnu-Rasgrp1m1Anu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp1m1Anu mutation (2 available); any Rasgrp1 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:104190 )
• CD44 is overexpressed on na=C3=AFve thymocytes and T cells in a T-cell-autonomous manner
autoimmune response ( J:104190 )
• subclinical autoimmune susceptibility

hematopoietic system
abnormal T cell differentiation ( J:104190 )
• CD44 is overexpressed on na=C3=AFve thymocytes and T cells in a T-cell-autonomous manner




Genotype
MGI:5565188
hm2
Allelic
Composition		 Rasgrp1m1Anu/Rasgrp1m1Anu
Genetic
Background		 involves: C57BL/6JSfdAnu * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp1m1Anu mutation (2 available); any Rasgrp1 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:207898 )
N
• mice exhibit normal frequency and number of mature CD4+ and CD8+ single positive thymocytes, regulatory T cell differentiation, positive selection and clonal deletion
abnormal CD4-positive, alpha beta T cell morphology ( J:207898 )
• accumulation of PD1+ Helios+ CD4+ T cells
increased effector memory CD4-positive, alpha-beta T cell number ( J:207898 )
• activated or memory/effector CD4+ cells

hematopoietic system
abnormal CD4-positive, alpha beta T cell morphology ( J:207898 )
• accumulation of PD1+ Helios+ CD4+ T cells
increased effector memory CD4-positive, alpha-beta T cell number ( J:207898 )
• activated or memory/effector CD4+ cells




Genotype
MGI:5565187
ht3
Allelic
Composition		 Rasgrp1m1Anu/Rasgrp1+
Genetic
Background		 involves: C57BL/6JSfdAnu * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp1m1Anu mutation (2 available); any Rasgrp1 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system




Genotype
MGI:5565189
cx4
Allelic
Composition		 Mtorchino/Mtorchino
Rasgrp1m1Anu/Rasgrp1m1Anu
Genetic
Background		 involves: C57BL/6JAnu * C57BL/6JSfdAnu * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtorchino mutation (1 available); any Mtor mutation (115 available)
Rasgrp1m1Anu mutation (2 available); any Rasgrp1 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:207898 )
N
• suppressed accumulation of PD1+ Helios+ CD4+ T cells compared with Rasgrp1m1Anu homozygotes

hematopoietic system
hematopoietic system phenotype ( J:207898 )
N
• hematopoietic cells transferred into bone marrow chimeras exhibit normal frequency of animals with antinuclear autoantibodies compared with chimeras receiving Rasgrp1m1Anu cells




Genotype
MGI:5565190
cx5
Allelic
Composition		 Cd79am1Anu/Cd79am1Anu
Rasgrp1m1Anu/Rasgrp1m1Anu
Genetic
Background		 involves: C57BL/6JSfdAnu * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79am1Anu mutation (2 available); any Cd79a mutation (24 available)
Rasgrp1m1Anu mutation (2 available); any Rasgrp1 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:207898 )
N
• profoundly suppressed accumulation of PD1+ Helios+ CD4+ T cells compared with Rasgrp1m1Anu homozygotes
• restored number of effector/memory and regulatory CD4+ T cells compared with Rasgrp1m1Anu homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory