mortality/aging
• most mice die in the first day after birth
(J:165694)
• however, mice that survive shortly after birth exhibit normal survival
(J:165694)
|
reproductive system
small testis
(
J:164874
)
• greatly in 3 of 8 surviving adult male mice
|
nervous system
• olfactory neurons grown in 3 dimensional extracellular matrix exhibit reduced outgrowth compared with similarly treated wild-type neurons
|
• at P0.5, fewer gonadotropin releasing hormone (GnRH) positive cells are found in the preoptic region of the hypothalamus compared to in wild-type mice
|
• olfactory bulbs exhibit severe defects in lamination compared with wild-type
• the nerve fiber layer is completely lost unlike in wild-type mice
|
• mice exhibit a lack of the stereotypic circular arrangement of interneurons in the glomerular layer unlike wild-type mice
|
• mice lack a distinct mitral cell layer unlike in wild-type mice
|
• in 23 of 25 mice at P0.5
|
• by E13.5, olfactory sensory neuron axons exhibit impaired ability to reach the developing olfactory bulb stalling outside the pial basement membrane unlike in wild-type mice
|
• by E13.5, olfactory sensory neuron axons exhibit impaired ability to reach the developing olfactory bulb stalling outside the pial basement membrane unlike in wild-type mice
|
• at P0.5, mice exhibit deficient innervation in the olfactory bulb compared with wild-type mice
|
• at P0.5, the olfactory bulb exhibits increased apoptosis in the epithelium compared to in wild-type mice
• however, no increase in apoptosis is observed at E14.5
|
behavior/neurological
• in most mice
|
endocrine/exocrine glands
• at P0.5, fewer gonadotropin releasing hormone (GnRH) positive cells are found in the preoptic region of the hypothalamus compared to in wild-type mice
|
small testis
(
J:164874
)
• greatly in 3 of 8 surviving adult male mice
|
cellular
• olfactory neurons grown in 3 dimensional extracellular matrix exhibit reduced outgrowth compared with similarly treated wild-type neurons
|