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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fcrlbtm1Pdb
targeted mutation 1, Peter D Burrows
MGI:4838081
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fcrlbtm1Pdb/Fcrlbtm1Pdb B6.129-Fcrlbtm1Pdb MGI:4838082


Genotype
MGI:4838082
hm1
Allelic
Composition		 Fcrlbtm1Pdb/Fcrlbtm1Pdb
Genetic
Background		 B6.129-Fcrlbtm1Pdb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcrlbtm1Pdb mutation (0 available); any Fcrlb mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased IgG1 level ( J:165408 )
• Background Sensitivity: enhanced primary and secondary responses to NP16CGC immunization, however author speculates that the enhanced antibody response may be due to a SNP of 129 origin in the Fcgr2b promoter.
increased anti-nuclear antigen antibody level ( J:165408 )
• Background Sensitivity: a marginal increase in ANAs compared to C57BL/6 mice however C57BL/6 mice consomic for similar region of chromsomome 1 have a similar increase in ANAs

hematopoietic system
increased IgG1 level ( J:165408 )
• Background Sensitivity: enhanced primary and secondary responses to NP16CGC immunization, however author speculates that the enhanced antibody response may be due to a SNP of 129 origin in the Fcgr2b promoter.




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory