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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Alb1-GP33/H2-Kb)1Hpi
transgene insertion 1, Hanspeter Pircher
MGI:4838097
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Alb1-GP33/H2-Kb)1Hpi/0
Tg(Alb1-HBV)66Bri/0 		involves: C57BL/6 * C57BL/10 * DBA/2 MGI:4838100
cx2
 		Tg(Alb1-GP33/H2-Kb)1Hpi/0
Tg(Alb1-HBV)66Bri/0
Tg(TcrLCMV)318Sdz/0 		involves: C57BL/6 * C57BL/10 * DBA/2 MGI:4838101
cx3
 		Tg(Alb1-GP33/H2-Kb)1Hpi/0
Tg(TcrLCMV)318Sdz/0 		involves: C57BL/6 * DBA/2 MGI:4838099
tg4
 		Tg(Alb1-GP33/H2-Kb)1Hpi/0 B6.Cg-Tg(Alb1-GP33/H2-Kb)1Hpi MGI:4838098


Genotype
MGI:4838100
cx1
Allelic
Composition		 Tg(Alb1-GP33/H2-Kb)1Hpi/0
Tg(Alb1-HBV)66Bri/0
Genetic
Background		 involves: C57BL/6 * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Alb1-GP33/H2-Kb)1Hpi mutation (0 available)
Tg(Alb1-HBV)66Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
liver inflammation ( J:162605 )
• in response to the adoptive transfer of Tg(TcrLCMV)318Sdz T cell cells followed by LCMV infection

liver/biliary system
liver inflammation ( J:162605 )
• in response to the adoptive transfer of Tg(TcrLCMV)318Sdz T cell cells followed by LCMV infection

homeostasis/metabolism
increased circulating alanine transaminase level ( J:162605 )
• in response to the adoptive transfer of Tg(TcrLCMV)318Sdz T cell cells followed by LCMV infection




Genotype
MGI:4838101
cx2
Allelic
Composition		 Tg(Alb1-GP33/H2-Kb)1Hpi/0
Tg(Alb1-HBV)66Bri/0
Tg(TcrLCMV)318Sdz/0
Genetic
Background		 involves: C57BL/6 * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Alb1-GP33/H2-Kb)1Hpi mutation (0 available)
Tg(Alb1-HBV)66Bri mutation (1 available)
Tg(TcrLCMV)318Sdz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
liver inflammation ( J:162605 )
• only weak signs of hepatitis (less than 100 U/L) after LCMV infection

liver/biliary system
liver inflammation ( J:162605 )
• only weak signs of hepatitis (less than 100 U/L) after LCMV infection




Genotype
MGI:4838099
cx3
Allelic
Composition		 Tg(Alb1-GP33/H2-Kb)1Hpi/0
Tg(TcrLCMV)318Sdz/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:162605 )
• a reduction of CD8 single-positive (SP) thymocytes expressing the tg TCR
• the periphery exhibits an 8- to 10-fold decrease compared with that of single-tg TCR mice

immune system
decreased CD8-positive, alpha-beta T cell number ( J:162605 )
• a reduction of CD8 single-positive (SP) thymocytes expressing the tg TCR
• the periphery exhibits an 8- to 10-fold decrease compared with that of single-tg TCR mice




Genotype
MGI:4838098
tg4
Allelic
Composition		 Tg(Alb1-GP33/H2-Kb)1Hpi/0
Genetic
Background		 B6.Cg-Tg(Alb1-GP33/H2-Kb)1Hpi
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating alanine transaminase level ( J:162605 )
• activated CD8 T cells from Tg(TcrLCMV)318Sdz induce high levels of transaminase in nonirradiated mice compared to noniradiated wild-type mice

immune system
abnormal cytotoxic T cell physiology ( J:162605 )
• 10 fold decrease in GP33-specific effector CTL function after infected with LCMV, compared to C57BL/6 mice
decreased cytotoxic T cell cytolysis ( J:162605 )
• a decrease in specific lysis at low GP33 peptide concentration by CTL from LCMV infected mice

hematopoietic system
abnormal cytotoxic T cell physiology ( J:162605 )
• 10 fold decrease in GP33-specific effector CTL function after infected with LCMV, compared to C57BL/6 mice
decreased cytotoxic T cell cytolysis ( J:162605 )
• a decrease in specific lysis at low GP33 peptide concentration by CTL from LCMV infected mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory