Phenotypes associated with this allele

• Allele Symbol: Pou2f1^tm1Cav
• Allele Name: targeted mutation 1, Fatima Cavaleri
• Allele ID: MGI:4838111
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pou2f1^tm1Cav/Pou2f1^tm1Cav	involves: 129P2/OlaHsd * C57BL/6	MGI:4838112

Genotype
MGI:4838112

hm1

• Allelic Composition: Pou2f1^tm1Cav/Pou2f1^tm1Cav
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:165572 )

• die between E7.5 and E9.0 with only resorbed embryos found at E9.5

• tetraploid complementation prolongs survival slightly but all embryos are still lost by E10.5

embryo

abnormal embryo development ( J:165572 )

• embryos are oval or asymmetric in shape at about E7.5

embryonic growth arrest ( J:165572 )

• at about E7.5 embryos appear to have arrested at the egg cylinder stage

• following tetraploid complementation embryos at E9.5 appear to have arrested at the neurula stage with no more than 4 - 5 somites

decreased embryo size ( J:165572 )

• at E7.0

abnormal embryonic-extraembryonic boundary morphology ( J:165572 )

• no evident demarcation between embryonic and extraembryonic tissue is detected at about E7.5

absent ectoplacental cone ( J:165572 )

• lack a structured ectoplacental cone at E7.0

abnormal extraembryonic ectoderm morphology ( J:165572 )

• expression analysis indicates an extraembryonic ectoderm like compartment forms but is severely compromised in size

• unable to derive trophoblast stem cells from homozygous embryos

abnormal anterior visceral endoderm morphology ( J:165572 )

• expression analysis indicates expansion of the anterior visceral endoderm into more posterior regions

growth/size/body

decreased embryo size ( J:165572 )

• at E7.0