All Phenotypes Ccn2<tm2Mae> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ccn2^tm1Mae/Ccn2^tm2Mae	involves: 129S6/SvEvTac	MGI:4838157
cn2	Ccn2^tm2Mae/Ccn2⁺ Tg(EIIa-cre)C5379Lmgd/?	involves: 129S6/SvEvTac	MGI:4838160
cn3	Ccn2^tm2Mae/Ccn2⁺ Tg(CAG-cre/Esr1*)5Amc/?	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:4838161
cn4	Ccn2^tm2Mae/Ccn2⁺ Tg(EIIa-cre)C5379Lmgd/?	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:4838158

Allelic Composition	Ccn2^tm1Mae/Ccn2^tm2Mae
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccn2^tm1Mae mutation (1 available); any Ccn2 mutation (29 available)
Ccn2^tm2Mae mutation (1 available); any Ccn2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:165111 )

• pups are born in the expected ratio

• no overt phenotype

• reproduce adequately and are healthy

Allelic Composition	Ccn2^tm2Mae/Ccn2⁺ Tg(EIIa-cre)C5379Lmgd/?
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccn2^tm2Mae mutation (1 available); any Ccn2 mutation (29 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:165111 )

• Background Sensitivity: no heterozygous embryos after E12.5

embryo

abnormal pharyngeal arch development ( J:165111 )

• pharyngeal arches remain open

embryonic growth retardation ( J:165111 )

• small and embryonic development is delayed at E10.5

cardiovascular system

abnormal vasculogenesis ( J:165111 )

• less visible vasculature

craniofacial

abnormal facial morphology ( J:165111 )

• shortened face in mice surviving to adulthood (4/81)

small ears ( J:165111 )

• in mice surviving to adulthood (4/81)

limbs/digits/tail

short tail ( J:165111 )

• in mice surviving to adulthood (4/81)

kinked tail ( J:165111 )

• in mice surviving to adulthood (4/81)

skeleton

abnormal bone structure ( J:165111 )

• smaller bone area in mice surviving to adulthood (4/81)

decreased bone mineral content ( J:165111 )

• in mice surviving to adulthood (4/81)

growth/size/body

abnormal facial morphology ( J:165111 )

• shortened face in mice surviving to adulthood (4/81)

small ears ( J:165111 )

• in mice surviving to adulthood (4/81)

embryonic growth retardation ( J:165111 )

• small and embryonic development is delayed at E10.5

decreased lean body mass ( J:165111 )

• in mice surviving to adulthood (4/81)

hearing/vestibular/ear

small ears ( J:165111 )

• in mice surviving to adulthood (4/81)

Allelic Composition	Ccn2^tm2Mae/Ccn2⁺ Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccn2^tm2Mae mutation (1 available); any Ccn2 mutation (29 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:165111 )

• tamoxifen induced cre expression has no effect on phenotype up to 3 months after treatment

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:165111 )

• Background Sensitivity: no heterozygous embryos after E14.5

embryo

embryonic growth retardation ( J:165111 )

• small and embryonic development is delayed

decreased embryo size ( J:165111 )

cardiovascular system

abnormal vasculogenesis ( J:165111 )

• poor vascularization at E13.5-14.5

vision/eye

abnormal eye development ( J:165111 )

• eye is less developed at E13.5-14.5

craniofacial

short face ( J:165111 )

• shortened face in mice surviving to adulthood (4/81)

facial cleft ( J:165111 )

lateral facial cleft ( J:165111 )

• at E13.5-14.5

midline facial cleft ( J:165111 )

• at E13.5-14.5

small ears ( J:165111 )

• in mice surviving to adulthood (4/81)

limbs/digits/tail

short tail ( J:165111 )

• in mice surviving to adulthood (4/81)

kinked tail ( J:165111 )

• in mice surviving to adulthood (4/81)

skeleton

abnormal bone structure ( J:165111 )

• smaller bone area in mice surviving to adulthood (4/81)

decreased bone mineral content ( J:165111 )

• in mice surviving to adulthood (4/81)

growth/size/body

short face ( J:165111 )

• shortened face in mice surviving to adulthood (4/81)

facial cleft ( J:165111 )

lateral facial cleft ( J:165111 )

• at E13.5-14.5

midline facial cleft ( J:165111 )

• at E13.5-14.5

small ears ( J:165111 )

• in mice surviving to adulthood (4/81)

embryonic growth retardation ( J:165111 )

• small and embryonic development is delayed

decreased embryo size ( J:165111 )

decreased lean body mass ( J:165111 )

• in mice surviving to adulthood (4/81)

hearing/vestibular/ear

small ears ( J:165111 )

• in mice surviving to adulthood (4/81)

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