Analysis Tools
mortality/aging
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• when the knock-out allele is maternally inherited, no female mice are recovered after E11.5
• however, male lethality is normal and paternal inheritance of the knock-out allele does not affect embryonic viability
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reproductive system
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• female mice cannot be produced from maternal transmission of the knock-out allele
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embryo
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• when the knock-out allele is maternally inherited, developmental abnormalities in female embryos occur as early as implantation or shortly thereafter
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• when the knock-out allele is maternally inherited, most to all of the extraembryonic tissues derived from the extraembryonic trophoblast in female embryos is missing in the placenta unlike in wild-type mice
• however, maternal decidual is normal
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cellular
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• when the knock-out allele is maternally inherited, X inactivation of the paternal X chromosome is absent unlike in wild-type cells
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