mortality/aging
• no mice are detected after E12.5
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Allele Symbol Allele Name Allele ID |
Pdpk1tm1.1Daca targeted mutation 1.1, Doreen A Cantrell MGI:4838167 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no mice are detected after E12.5
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• T cells are decreased in the liver compared to in wild-type mice
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• NK1.1-/CD44- stage 1 through 3 cells are decreased compared to in wild-type mice
• invariant NK T cell numbers in peripheral tissues (spleen, blood, and liver) is severely decreased compared to in wild-type mice
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• CD8+ thymocytes exhibit reduced surface expression of CD8 compared to in wild-type mice
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• T cells are decreased in the liver compared to in wild-type mice
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• NK1.1-/CD44- stage 1 through 3 cells are decreased compared to in wild-type mice
• invariant NK T cell numbers in peripheral tissues (spleen, blood, and liver) is severely decreased compared to in wild-type mice
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• CD8+ thymocytes exhibit reduced surface expression of CD8 compared to in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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