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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdpk1tm1.1Daca
targeted mutation 1.1, Doreen A Cantrell
MGI:4838167
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pdpk1tm1.1Daca/Pdpk1tm1.1Daca involves: 129P2/OlaHsd * BALB/c MGI:4838170
cn2
 		Pdpk1tm1Mlw/Pdpk1tm1.1Daca
Tg(Cd4-cre)1Cwi/0 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2 MGI:4838171


Genotype
MGI:4838170
hm1
Allelic
Composition		 Pdpk1tm1.1Daca/Pdpk1tm1.1Daca
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpk1tm1.1Daca mutation (0 available); any Pdpk1 mutation (138 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4838171
cn2
Allelic
Composition		 Pdpk1tm1Mlw/Pdpk1tm1.1Daca
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpk1tm1.1Daca mutation (0 available); any Pdpk1 mutation (138 available)
Pdpk1tm1Mlw mutation (0 available); any Pdpk1 mutation (138 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:165626 )
• T cells are decreased in the liver compared to in wild-type mice
decreased NK T cell number ( J:165626 )
• NK1.1-/CD44- stage 1 through 3 cells are decreased compared to in wild-type mice
• invariant NK T cell numbers in peripheral tissues (spleen, blood, and liver) is severely decreased compared to in wild-type mice
abnormal CD8-positive, alpha beta T cell morphology ( J:165626 )
• CD8+ thymocytes exhibit reduced surface expression of CD8 compared to in wild-type mice

hematopoietic system
decreased T cell number ( J:165626 )
• T cells are decreased in the liver compared to in wild-type mice
decreased NK T cell number ( J:165626 )
• NK1.1-/CD44- stage 1 through 3 cells are decreased compared to in wild-type mice
• invariant NK T cell numbers in peripheral tissues (spleen, blood, and liver) is severely decreased compared to in wild-type mice
abnormal CD8-positive, alpha beta T cell morphology ( J:165626 )
• CD8+ thymocytes exhibit reduced surface expression of CD8 compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory